Ling J, Chau P Y
Department of Microbiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
Epidemiol Infect. 1987 Oct;99(2):307-21. doi: 10.1017/s0950268800067789.
Plasmids present in multiply-resistant salmonella strains including Salmonella typhimurium, S. johannesburg, S. wandsworth, S. derby, S. newport, S. london and S. choleraesuis causing diarrhoea in patients in Queen Mary Hospital in Hong Kong from 1973-82 were studied. In multiply-resistant S. typhimurium, plasmids belonging to groups FIme, H1 or H2 and plasmids encoding trimethoprim-resistance which were compatible with standard plasmids of testable incompatibility groups were detected. In S. johannesburg, both the ASTCKSu- and ASCKSu-resistant strains which were predominant in two consecutive periods of an outbreak were found to harbour the same plasmid which belonged to the incompatibility group FIme. S. wandsworth strains isolated from a hospital outbreak in 1980 harboured an identical R-plasmid belonging to group N. A few strains of the other salmonellae showing resistance to multiple antibiotics were found to harbour R-plasmids belonging to groups H1, H2 and FIme. The only salmonella of the enteric fever group resistant to ampicillin, chloramphenicol and trimethoprim was an S. paratyphi B strain. The resistances were encoded on a plasmid of an unknown incompatibility group. The occurrence and distribution of plasmids in these salmonellae isolated within the 10-year period are discussed.
对1973年至1982年期间从香港玛丽医院腹泻患者中分离出的多重耐药沙门氏菌菌株（包括鼠伤寒沙门氏菌、约翰内斯堡沙门氏菌、万兹沃思沙门氏菌、德比沙门氏菌、纽波特沙门氏菌、伦敦沙门氏菌和猪霍乱沙门氏菌）中的质粒进行了研究。在多重耐药的鼠伤寒沙门氏菌中，检测到属于FIme、H1或H2组的质粒以及编码甲氧苄啶抗性且与可测试不相容性组的标准质粒相容的质粒。在约翰内斯堡沙门氏菌中，发现在一次疫情连续两个时期占主导地位的对ASTCKSu和ASCKSu耐药的菌株都携带属于不相容性组FIme的同一质粒。1980年从一次医院疫情中分离出的万兹沃思沙门氏菌菌株携带一个属于N组的相同R质粒。发现其他一些对多种抗生素耐药的沙门氏菌菌株携带属于H1、H2和FIme组的R质粒。唯一对氨苄青霉素、氯霉素和甲氧苄啶耐药的伤寒组沙门氏菌是一株副伤寒乙杆菌。这些抗性由一个未知不相容性组的质粒编码。讨论了在这10年期间分离出的这些沙门氏菌中质粒的发生和分布情况。
