质粒介导的甲氧苄啶耐药性在肠杆菌中日益重要：两项为期六个月的临床调查
Increasing importance of plasmid-mediated trimethoprim resistance in enterobacteria: two six-month clinical surveys.
作者信息
Towner K J, Pearson N J, Pinn P A, O'Grady F
出版信息
Br Med J. 1980 Feb 23;280(6213):517-9. doi: 10.1136/bmj.280.6213.517.
Abstract
All clinical isolates of enterobacteria received at the laboratory were monitored for trimethoprim resistance over six months in 1978. The survey was repeated in 1979 and the incidence of trimethoprim resistance showed a slight decrease, but the proportion of resistant strains owing their trimethoprim resistance to transferable R plasmids had almost trebled. There was also a large increase in the proportion of resistant strains exhibiting high-level non-transferable trimethoprim resistance. These findings suggest transposition of genes conferring trimethoprim resistance from plasmids to the bacterial chromosome.
摘要
1978年，实验室接收的所有肠道杆菌临床分离株均接受了为期六个月的甲氧苄啶耐药性监测。1979年重复了这项调查，甲氧苄啶耐药性的发生率略有下降，但因可转移R质粒而产生甲氧苄啶耐药性的菌株比例几乎增加了两倍。表现出高水平非转移性甲氧苄啶耐药性的耐药菌株比例也大幅增加。这些发现表明，赋予甲氧苄啶耐药性的基因从质粒转位到了细菌染色体上。
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本文引用的文献
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