Li Yilun, Ma Li
The Fourth Hospital of Hebei Medical University, Shi Jiazhuang City, Hebei Province, China.
Medicine (Baltimore). 2020 Nov 6;99(45):e23105. doi: 10.1097/MD.0000000000023105.
The relationship between solar ultraviolet radiation and the risk of breast cancer is conflicting. The purpose of our study was to quantitatively assess the relationship between solar ultraviolet radiation and breast cancer risk and to analyze related factors such as age and sunscreen use.Articles indexed in PubMed and Embase and published between January 2005 and March 2020 were searched for relevant keywords. The relative risk was calculated using random-effect or fixed-effect models in the meta-analysis and dose-response meta-analysis, which were conducted according to the Meta-Analyses of Observational Studies in Epidemiology reporting guidelines. Sensitivity analyses for heterogeneity and publication bias were evaluated.Six studies were eligible for inclusion in the meta-analysis, and three of these were included in the dose-response analysis. We found a correlation between exposure to solar ultraviolet radiation and breast cancer risk (relative risk: 0.70, 95% confidence interval: 0.65, 0.75). We also found a linear dose-response relationship between the exposure and breast cancer risk (relative risk: 0.86, 95% confidence interval: 0.81, 0.91) in women over 40. Not tanning and covering the limbs were associated with breast cancer risk, but sunscreen use was not.Exposure to solar ultraviolet radiation is negatively correlated with breast cancer risk, and the association is linear in women over 40. This is the first dose-response meta-analysis on the topic, and the influence of factors such as estrogen receptor status, occupational exposure, and ethnicity requires in-depth study.
太阳紫外线辐射与乳腺癌风险之间的关系存在争议。我们研究的目的是定量评估太阳紫外线辐射与乳腺癌风险之间的关系，并分析年龄和防晒措施使用等相关因素。在PubMed和Embase数据库中检索2005年1月至2020年3月期间发表的文章，查找相关关键词。在荟萃分析和剂量反应荟萃分析中，使用随机效应或固定效应模型计算相对风险，这些分析是根据流行病学观察性研究的荟萃分析报告指南进行的。评估了异质性和发表偏倚的敏感性分析。六项研究符合纳入荟萃分析的条件，其中三项纳入了剂量反应分析。我们发现太阳紫外线辐射暴露与乳腺癌风险之间存在相关性（相对风险：0.70，95%置信区间：0.65，0.75）。我们还发现，40岁以上女性的暴露与乳腺癌风险之间存在线性剂量反应关系（相对风险：0.86，95%置信区间：0.81，0.91）。不晒太阳和遮盖四肢与乳腺癌风险相关，但防晒措施的使用与之无关。太阳紫外线辐射暴露与乳腺癌风险呈负相关，且在40岁以上女性中这种关联是线性的。这是关于该主题的首次剂量反应荟萃分析，雌激素受体状态、职业暴露和种族等因素的影响需要深入研究。
