2型糖尿病患者补充维生素C：系统评价与荟萃分析方案
Ascorbic acid supplementation in type 2 diabetes mellitus: A protocol for systematic review and meta-analysis.
作者信息
Shi Lipeng, Du Xuqin, Guo Pei, Huang Lumei, Qi Peng, Gong Qianhui
机构信息
Clinical Department, Dianjiang Hospital of Traditional Chinese Medicine, Dianjiang, Chongqing.
College of Traditional Chinese Medicine, Chongqing Medical University.
出版信息
Medicine (Baltimore). 2020 Nov 6;99(45):e23125. doi: 10.1097/MD.0000000000023125.
BACKGROUND
Diabetes is one of the most common chronic diseases in the world. In recent years, with the continuous improvement of people's living standards and changes in dietary structure, the incidence of diabetes is gradually increasing. Studies have shown that ascorbic acid supplementation can reduce blood glucose, increase insulin synthesis and secretion, improve insulin resistance, and reduce the occurrence and development of complications of type 2 diabetes mellitus (T2DM). However, relevant studies have common problems such as the lack of large sample studies and low quality of included studies. Therefore, it is needed that we meta-analyze the clinical trials with high quality to elucidate the efficacy and safety of ascorbic acid supplementation in patients with T2DM.
METHODS
We will search randomized controlled trials published by PubMed, Embase, the Cochrane Library, Web of Science, and the Clinical Trials.gov website from inception to August 2020 on the effects of ascorbic acid supplementation on blood glucose, glycosylated hemoglobin, serum insulin, insulin resistance and other variables in T2DM patients with no language restrictions. The retrieval adopts the combination of medical subject headings and random words, and traces the references of the included literature to supplement the acquisition of relevant literature. Two researchers will independently screen the retrieved literature, extract the data and cross-check, and the Review Manage software V5.3.0 will be utilized for meta-analysis.
RESULTS
Our study will provide a high-quality and in-depth comprehensive analysis of the effects of ascorbic acid supplementation on blood glucose control, glycosylated hemoglobin and insulin resistance in type 2 diabetic patients.
CONCLUSION
This systematic review and meta-analysis concerning randomized controlled trials of ascorbic acid supplementation for type 2 diabetic patients will provide a new direction and strong evidence to evaluate whether ascorbic acid supplementation is of benefit to glucose control and insulin resistance in T2DM.
PROSPERO REGISTRATION NUMBER
CRD 42019146826.
背景
糖尿病是世界上最常见的慢性病之一。近年来，随着人们生活水平的不断提高和饮食结构的变化，糖尿病的发病率逐渐上升。研究表明，补充维生素C可以降低血糖，增加胰岛素的合成与分泌，改善胰岛素抵抗，减少2型糖尿病（T2DM）并发症的发生与发展。然而，相关研究存在缺乏大样本研究、纳入研究质量较低等共性问题。因此，需要对高质量的临床试验进行荟萃分析，以阐明补充维生素C对T2DM患者的疗效和安全性。
方法
我们将检索PubMed、Embase、Cochrane图书馆、Web of Science和Clinical Trials.gov网站从创建至2020年8月发表的关于补充维生素C对T2DM患者血糖、糖化血红蛋白、血清胰岛素、胰岛素抵抗等变量影响的随机对照试验，无语言限制。检索采用医学主题词与随机词相结合的方式，并追溯纳入文献的参考文献以补充获取相关文献。两名研究人员将独立筛选检索到的文献，提取数据并交叉核对，使用Review Manage软件V5.3.0进行荟萃分析。
结果
我们的研究将对补充维生素C对2型糖尿病患者血糖控制、糖化血红蛋白和胰岛素抵抗的影响提供高质量且深入的综合分析。
结论
这项关于补充维生素C治疗2型糖尿病患者的随机对照试验的系统评价和荟萃分析将为评估补充维生素C是否有益于T2DM患者的血糖控制和胰岛素抵抗提供新的方向和有力证据。
PROSPERO注册号：CRD 42019146826。
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