Paul W E
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
FASEB J. 1987 Dec;1(6):456-61. doi: 10.1096/fasebj.1.6.3315808.
Lymphokines are multifunctional T cell products that profoundly regulate the activation, growth, and differentiation of many cell types, most notably T cells and B cells. One of the lymphokines with the broadest range of actions is interleukin 4/B cell stimulatory factor 1. The characteristics, function, and regulation of interleukin 4 are reviewed as part of an overall discussion of the mechanism through which T cell-derived lymphokines control immune responses in vivo and in vitro.
淋巴因子是多功能的T细胞产物,可深刻调节多种细胞类型的激活、生长和分化,其中最显著的是T细胞和B细胞。作用范围最广的淋巴因子之一是白细胞介素4/ B细胞刺激因子1。作为对T细胞衍生的淋巴因子在体内和体外控制免疫反应机制的全面讨论的一部分,本文综述了白细胞介素4的特性、功能和调节。