Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Department of Herbal Pharmacology, College of Korean Medicine, Graduate School, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Nutrients. 2020 Nov 4;12(11):3392. doi: 10.3390/nu12113392.
and are major crops cultivated worldwide. In East Asia, both flowers and leaves are traditionally used for therapeutic purposes and consumed as teas for weight loss. Herein, we investigated the anti-obesity effects of an herbal extract mixture of and (HT077) and the underlying mechanism using a high-fat diet (HFD)-induced obesity model. Male C57BL/6 mice were fed a normal diet, HFD, HFD containing 0.02% orlistat (positive control), or HFD containing 0.1, 0.2, or 0.4% HT077 for 12 weeks. HT077 significantly reduced final body weights, weight gain, abdominal fat weights, liver weights, and hepatic levels of triglycerides and total cholesterol. HT077 also lowered glucose, cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and leptin levels and increased AST/ALT and adiponectin/leptin ratios and adiponectin levels. Real-time polymerase chain reaction analysis showed that HT077 decreased the expression of lipogenic genes and increased the expression of fatty acid oxidation-related genes in adipose tissue. Our results indicate that HT077 exerts anti-obesity effects and prevents the development of obesity-related metabolic disorders. These beneficial effects might be partially attributed to ameliorating adipokine imbalances and regulating lipid synthesis and fatty acid oxidation in adipose tissue.
和 都是全球范围内主要种植的农作物。在东亚，花和叶都被传统地用于治疗目的，并作为减肥茶饮用。在此，我们使用高脂肪饮食（HFD）诱导的肥胖模型，研究了 和 （HT077）草药提取物混合物的减肥效果及其潜在机制。雄性 C57BL/6 小鼠分别喂食正常饮食、HFD、含 0.02%奥利司他的 HFD（阳性对照）或含 0.1%、0.2%或 0.4% HT077 的 HFD，共 12 周。HT077 显著降低了最终体重、体重增加、腹部脂肪重量、肝脏重量以及肝脏甘油三酯和总胆固醇水平。HT077 还降低了血糖、胆固醇、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）和瘦素水平，增加了 AST/ALT 和脂联素/瘦素比值以及脂联素水平。实时聚合酶链反应分析显示，HT077 降低了脂肪组织中脂肪生成基因的表达，增加了脂肪酸氧化相关基因的表达。我们的结果表明，HT077 具有减肥作用，并可预防肥胖相关代谢紊乱的发生。这些有益作用可能部分归因于改善了脂肪因子失衡，并调节了脂肪组织中的脂质合成和脂肪酸氧化。
