Jamróz Witold, Pyteraf Jolanta, Kurek Mateusz, Knapik-Kowalczuk Justyna, Szafraniec-Szczęsny Joanna, Jurkiewicz Karolina, Leszczyński Bartosz, Wróbel Andrzej, Paluch Marian, Jachowicz Renata
Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.
Division of Biophysics and Molecular Physics, Institute of Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland.
Materials (Basel). 2020 Nov 4;13(21):4961. doi: 10.3390/ma13214961.
The simplicity of object shape and composition modification make additive manufacturing a great option for customized dosage form production. To achieve this goal, the correlation between structural and functional attributes of the printed objects needs to be analyzed. So far, it has not been deeply investigated in 3D printing-related papers. The aim of our study was to modify the functionalities of printed tablets containing liquid crystal-forming drug itraconazole by introducing polyvinylpyrrolidone-based polymers into the filament-forming matrices composed predominantly of poly(vinyl alcohol). The effect of the molecular reorganization of the drug and improved tablets' disintegration was analyzed in terms of itraconazole dissolution. Micro-computed tomography was applied to analyze how the design of a printed object (in this case, a degree of an infill) affects its reproducibility during printing. It was also used to analyze the structure of the printed dosage forms. The results indicated that the improved disintegration obtained due to the use of KollidonCL-M was more beneficial for the dissolution of itraconazole than the molecular rearrangement and liquid crystal phase transitions. The lower infill density favored faster dissolution of the drug from printed tablets. However, it negatively affected the reproducibility of the 3D printed object.
物体形状和成分修改的简易性使增材制造成为定制剂型生产的理想选择。为实现这一目标，需要分析打印物体的结构和功能属性之间的相关性。到目前为止，在与3D打印相关的论文中尚未对此进行深入研究。我们研究的目的是通过将基于聚乙烯吡咯烷酮的聚合物引入主要由聚乙烯醇组成的丝状成型基质中，来改变含有液晶形成药物伊曲康唑的打印片剂的功能。从伊曲康唑溶解的角度分析了药物分子重排和片剂崩解改善的效果。应用微计算机断层扫描来分析打印物体的设计（在这种情况下，填充度）如何影响其打印过程中的再现性。它还用于分析打印剂型的结构。结果表明，与分子重排和液晶相变相比，使用科利通CL-M获得的崩解改善对伊曲康唑的溶解更有益。较低的填充密度有利于药物从打印片剂中更快地溶解。然而，它对3D打印物体的再现性有负面影响。
