Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GR 54124, Greece.
Laboratory of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, GR 54124, Greece.
Eur J Pharm Sci. 2020 Apr 30;147:105291. doi: 10.1016/j.ejps.2020.105291. Epub 2020 Mar 2.
The aim of the current study was the development of pediatric-friendly 3D printed chocolate-based oral dosage forms. Corn syrup was used to both facilitate the incorporation of a lipophilic, namely ibuprofen or a hydrophilic, namely paracetamol, active compound that were used as model drugs and to enable 3D printing of the chocolate-based dosage forms. Physicochemical (differential scanning calorimetry, X-Ray diffraction, Fourier-Transform infrared spectroscopy, particle size distribution) and rheological studies were applied for the characterization of the prepared chocolate-based formulations. Texture profile analysis and in vitro digestion studies were performed in order to further analyze the texture attributes and to evaluate drug dissolution of the final dosage forms, respectively. In the present study, we reported on a facile method for the preparation of a 3D printed chewable chocolate-based dosage form with rapid and high release of both hydrophobic and hydrophilic drugs in simulated salivary fluid. The application of 3D printing technology enables accuracy in dose adjustment, while at the same time introducing the potential of patient's active involvement in customization of the design, textural and organoleptic properties of the final dosage form.
本研究的目的是开发适合儿科使用的 3D 打印巧克力型口服剂型。使用玉米糖浆来促进亲脂性（如布洛芬）或亲水性（如对乙酰氨基酚）活性化合物的掺入，这些活性化合物被用作模型药物，并使巧克力型剂型能够 3D 打印。应用物理化学（差示扫描量热法、X 射线衍射、傅里叶变换红外光谱、粒径分布）和流变学研究对制备的巧克力型配方进行了表征。进行质地分析和体外消化研究，分别进一步分析最终剂型的质地属性和评估药物溶出度。在本研究中，我们报告了一种简便的方法，用于制备 3D 打印可咀嚼巧克力型剂型，该剂型在模拟唾液中能快速和高度释放疏水性和亲水性药物。3D 打印技术的应用能够实现剂量调整的准确性，同时还具有患者主动参与定制最终剂型的设计、质地和感官特性的潜力。
