Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege, 4000 Liege, Belgium.
Laboratory of Pharmaceutical Technology and Biopharmacy, Department of Pharmacy, Center for Interdisciplinary Research on Medicines (CIRM), University of Liege, 4000 Liege, Belgium.
Int J Pharm. 2020 Apr 30;580:119200. doi: 10.1016/j.ijpharm.2020.119200. Epub 2020 Mar 8.
Poor aqueous solubility of active pharmaceutical ingredients (API) is nowadays a major issue in the pharmaceutical field. The combinatorial chemistry provides more and more API with a great therapeutic potential, but with a low aqueous solubility. Among the strategies to overcome this drawback, the use of amorphous solid dispersions (ASD), as well as the increase of surface area, is widely used. The three dimensional (3D) printing technologies appear to be innovative tools allowing the construction of any unconventional forms with different composition, structure or infill; especially by using ASD materials. This review aims to deliver notions about the different 3D printing techniques found in the literature to improve aqueous solubility of several API, namely nozzle-based method, inkjet methods and laser- based methods, as well as guide formulator in terms of formulation parameters that have to be optimized to allow the most suitable impression of innovative medicines.
如今，活性药物成分（API）的水溶性差是制药领域的一个主要问题。组合化学提供了越来越多具有巨大治疗潜力但水溶性差的 API。克服这一缺点的策略包括使用无定形固体分散体（ASD）以及增加表面积。三维（3D）打印技术似乎是创新工具，可以构建具有不同成分、结构或填充的任何非常规形状；特别是通过使用 ASD 材料。本文旨在介绍文献中发现的不同 3D 打印技术，以提高几种 API 的水溶性，包括基于喷嘴的方法、喷墨方法和基于激光的方法，并为配方设计师提供必须优化的配方参数方面的指导，以允许对创新药物进行最合适的压印。
