雷尼替丁、法莫替丁和奥美拉唑治疗十二指肠溃疡出血的比较
[Comparison between ranitidine, famotidine, and omeprazole in the treatment of bleeding duodenal ulcer].
作者信息
Maculotti L, Pradella P
机构信息
Divisione di Chirurgia Generale Andrea Ponti, Ospedale Niguarda Ca' Granda, Milano.
出版信息
Minerva Chir. 1995 Mar;50(3):279-81.
A trial was carried out to compare the efficacy and safety of ranitidine 300 mg die, famotidine 40 mg die and omeprazole 20 mg die in short-term treatment of bleeding duodenal ulcer in 3 groups of 15 patients. The healing rates after 2.4 weeks were 33.60% respectively with ranitidine, 40, 70% respectively with famotidine and 53, 93% respectively with omeprazole. All the drugs were well tolerated and the adverse events were infrequent and moderate. The recurrence rates after 6, 12 months were 20, 33% respectively with ranitidine, 13, 20% respectively with famotidine and only 7, 13% respectively with omeprazole. In our experience, omeprazole seems to be superior to famotidine and to ranitidine in the short-term treatment of bleeding duodenal ulcer, with the shortest relapse rate.
进行了一项试验，比较雷尼替丁300毫克每日一次、法莫替丁40毫克每日一次和奥美拉唑20毫克每日一次对三组各15例十二指肠溃疡出血患者的短期治疗效果和安全性。雷尼替丁治疗2、4周后的愈合率分别为33.60%，法莫替丁分别为40%、70%，奥美拉唑分别为53%、93%。所有药物耐受性良好，不良事件发生率低且程度较轻。雷尼替丁治疗6、12个月后的复发率分别为20%、33%，法莫替丁分别为13%、20%，而奥美拉唑仅分别为7%、13%。根据我们的经验，在十二指肠溃疡出血的短期治疗中，奥美拉唑似乎优于法莫替丁和雷尼替丁，复发率最短。
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