Department of Laboratory Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu, China.
Department of Endocrine and Metabolism, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Chengdu, China.
J Endocrinol Invest. 2021 Jul;44(7):1515-1523. doi: 10.1007/s40618-020-01461-9. Epub 2020 Nov 7.
There are still controversies about the impact of climatic and environmental factors on thyroid function parameters in healthy populations. We investigated the relationships between climate, air pollution exposure, and thyroid function fluctuations.
We retrospectively reviewed 327,913 individuals attending routine health checks from December 2013 to December 2018. We analyzed the associations between thyroid function and climatic factors using Spearman's correlation analysis. We explored the relationships between thyroid function and air pollution exposure using multiple linear regression analysis, after adjusting for age, sex, season, and outdoor temperature. We also performed subgroup analyses by age and sex and sensitivity analyses of different anti-thyroid peroxidase antibody status.
Thyroid-stimulating hormone (TSH) and free triiodothyronine (FT3) were negatively associated with outdoor temperature (r = - 0.66, P < 0.001; r = - 0.55, P < 0.001), while free thyroxine (FT4) and FT4/FT3 were positively associated with temperature (r = 0.35, P < 0.001; r = 0.79, P < 0.001). An increase of 10 μg/m in fine particulate matter ≤ 2.5 μm (PM2.5) was associated with a decrease of 0.12 pmol/L in FT4 and an increase of 0.07 pmol/L in FT3 (both P < 0.01). FT4/FT3 was significantly negatively associated with PM2.5 (coefficient: - 0.06, P < 0.01). These results remained robust in hierarchical analyses and sensitivity analyses.
Thyroid function parameters are associated with climate and air pollution exposure. These factors may influence variations in thyroid function. Our results also highlight the importance of public health interventions to reduce air pollution.
关于气候和环境因素对健康人群甲状腺功能参数的影响仍存在争议。我们研究了气候、空气污染暴露与甲状腺功能波动之间的关系。
我们回顾性分析了 2013 年 12 月至 2018 年 12 月期间参加常规健康检查的 327913 例个体。我们使用 Spearman 相关分析来分析甲状腺功能与气候因素之间的关系。在调整年龄、性别、季节和室外温度后，我们使用多元线性回归分析来探讨甲状腺功能与空气污染暴露之间的关系。我们还按年龄和性别进行了亚组分析，并对不同抗甲状腺过氧化物酶抗体状态进行了敏感性分析。
促甲状腺激素（TSH）和游离三碘甲状腺原氨酸（FT3）与室外温度呈负相关（r=-0.66，P<0.001；r=-0.55，P<0.001），而游离甲状腺素（FT4）和 FT4/FT3 与温度呈正相关（r=0.35，P<0.001；r=0.79，P<0.001）。细颗粒物（PM2.5）每增加 10μg/m，FT4 降低 0.12pmol/L，FT3 升高 0.07pmol/L（均 P<0.01）。FT4/FT3 与 PM2.5 显著负相关（系数：-0.06，P<0.01）。这些结果在分层分析和敏感性分析中仍然稳健。
甲状腺功能参数与气候和空气污染暴露有关。这些因素可能会影响甲状腺功能的变化。我们的研究结果还强调了采取公共卫生干预措施减少空气污染的重要性。
