Tam Abbas Ali, Fakı Sevgul, Demir Pervin, Ozdemir Didem, Topaloglu Oya, Ersoy Reyhan, Cakir Bekir
Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara 06800, Turkey.
Department of Endocrinology and Metabolism, Ankara City Hospital, Ankara 06800, Turkey.
J Clin Med. 2024 Nov 30;13(23):7293. doi: 10.3390/jcm13237293.
Although seasonal changes were suggested to be among the many factors that affect thyroid functions, this issue is still controversial. In this study, we aimed to investigate the possible relationship between seasonal changes and thyroid function. We retrospectively scanned all thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) values checked in our hospital between 2019 and 2023. Using the big data approach, we examined the relationship between TSH and thyroid hormones and monthly and seasonal recorded climatic changes, particularly the duration of daylight and temperature. A total of 195,534 serum samples were analyzed for TSH, 195,491 for FT3, and 195,487 for FT4. There were significant differences in the values of TSH, FT3, and FT4 between months ( = 0.001 for TSH, < 0.001 for FT3 and FT4). The months with the highest levels of TSH, FT3, and FT4 values were January, December, and June, while the months with the lowest levels were July, May, and March-April, respectively. The differences between the maximum and minimum median values were 14.5% for TSH, 4.9% for FT3, and 5.7% for FT4. From January to August, as the temperature rose, there was a decrease in TSH values. Between September and December, as the temperature decreased, an increase in TSH was observed. This study revealed that TSH, FT3, and FT4 show seasonal variability and change in temperature is an important factor that plays role in this variability. It would be appropriate to take these changes into consideration when interpreting thyroid function tests.
尽管季节变化被认为是影响甲状腺功能的众多因素之一，但这个问题仍然存在争议。在本研究中，我们旨在调查季节变化与甲状腺功能之间可能存在的关系。我们回顾性扫描了2019年至2023年期间在我院检查的所有促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）值。使用大数据方法，我们研究了TSH与甲状腺激素以及每月和季节性记录的气候变化之间的关系，特别是日照时长和温度。共分析了195,534份血清样本的TSH、195,491份的FT3和195,487份的FT4。TSH、FT3和FT4的值在各月份之间存在显著差异（TSH为 = 0.001，FT3和FT4为 < 0.001）。TSH、FT3和FT4值最高的月份分别是1月、12月和6月，而值最低的月份分别是7月、5月和3 - 4月。TSH的最大和最小中位数之间的差异为14.5%，FT3为4.9%，FT4为5.7%。从1月到8月，随着温度升高，TSH值下降。在9月至12月期间，随着温度下降，观察到TSH升高。本研究表明，TSH、FT3和FT4表现出季节性变化，温度变化是导致这种变化的一个重要因素。在解释甲状腺功能测试结果时考虑这些变化是合适的。
