Fakı Sevgül, Tam Abbas Ali, Demir Pervin, Özdemir Didem, Çuhacı Seyrek Fatma Neslihan, Köroğlu Ekin Yiğit, Topaloğlu Oya, Ersoy Reyhan, Çakır Bekir
Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, 6800 Ankara, Turkey.
Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Yıldırım Beyazıt University, 6800 Ankara, Turkey.
Life (Basel). 2025 Feb 26;15(3):365. doi: 10.3390/life15030365.
Thyroid hormones are essential for the proper functioning of the female reproductive system. Seasonal changes in thyroid hormones in women of reproductive age are not fully understood. we aimed to investigate seasonal changes in thyrotrophin and thyroid hormones in women of reproductive age.
Approximately 75,000 TSH and thyroid hormone levels measured in 32,935 women between 2019 and 2023 were evaluated on a monthly and seasonal basis. The analysis of means (ANOM) method was utilized to compare the mean transformed rank of each group or the overall mean transformed rank for TSH, FT3, and FT4 values across months and seasons.
The differences from the maximum to minimum median values were 13.3% for TSH, 5.2% for free T3, and 5.9% for free T4. TSH levels were significantly lower in summer and autumn and higher in winter and spring than the overall transformed mean. The rate of individuals with TSH levels below 2.5 mIU/L was higher in summer and autumn than in spring and winter.
TSH varies seasonally in women of reproductive age. It is appropriate to consider the season as well as other parameters that affect thyroid functions while evaluating thyroid hormones.
甲状腺激素对于女性生殖系统的正常运作至关重要。育龄女性甲状腺激素的季节性变化尚未完全明确。我们旨在研究育龄女性促甲状腺激素和甲状腺激素的季节性变化。
对2019年至2023年间32935名女性测量的约75000次促甲状腺激素（TSH）和甲状腺激素水平进行月度和季节性评估。采用均值分析（ANOM）方法比较各月份和季节中TSH、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）值的每组平均转换秩或总体平均转换秩。
TSH从最大值到最小值的中位数差异为13.3%，游离T3为5.2%，游离T4为5.9%。夏季和秋季的TSH水平显著低于总体转换均值，而冬季和春季则较高。TSH水平低于2.5 mIU/L的个体比例在夏季和秋季高于春季和冬季。
育龄女性的TSH存在季节性变化。在评估甲状腺激素时，考虑季节以及其他影响甲状腺功能的参数是合适的。
