儿童肥胖与炎症介质之间的关系。

The relationship between childhood obesity with inflammatory mediators.

机构信息

Marmara University, Pendik Education and Research Hospital, Microbiology and Blood Center, Turkey.

Sports Physiology, Marmara University, Pendik Education and Research Hospital, Turkey.

出版信息

J Pak Med Assoc. 2020 Oct;70(10):1737-1741. doi: 10.5455/JPMA.27772.

DOI:10.5455/JPMA.27772

PMID:33159744

Abstract

OBJECTIVE

To determine the association of various obesity markers with systemic immune-inflammatory index.

METHODS

The cross-sectional study was conducted at Marmara University, Istanbul, Turkey, from January 2018 to October 2018 and comprised children aged 6-16 years admitted to the outpatient clinic due to obesity. The patients were evaluated for height, weight, body mass index (BMI), fat percentage (F%), fat mass (FM) and fat-free mass (FFM). Waist circumference was measured and neutrophil, platelet and lymphocyte counts and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) were calculated on the basis of haemogram. Data was analysed using Number Cruncher Statistical System 2007.

RESULTS

Of the 335 subjects, 203(60.6%) were girls and 132(39.4%) were boys. Univariate analysis of girls showed the effects of BMI, F%, FM, FFM and WC on NLR. FM remained a significant and independent risk factor for NLR (p<0.01). The effects of BMI, F%, FFM and WC were not significant in multivariate model (p>0.05). Univariate analysis of girls also showed the effects of BMI, F%, FM, FFM and WC measurements on SII. F% remained a significant and independent risk factor on SII (p<0.01). The effects of BMI, fat mass, FFM and WC were not significant in multivariate model (p>0.05).

CONCLUSION

In this study, the increase of SII, NLR and thrombocyte in terms of weight, BMI, fat percentage and fat mass supports the increase of inflammation due to the increase of fat in obesity. In terms of comorbidities in obesity, SII and NLR suggest that there may be inflammatory biomarkers which can be used in follow-up.

摘要

目的

确定各种肥胖标志物与全身免疫炎症指数的相关性。

方法

本横断面研究于 2018 年 1 月至 10 月在土耳其伊斯坦布尔马尔马拉大学进行，纳入因肥胖而到门诊就诊的 6-16 岁儿童。对患者进行身高、体重、体重指数（BMI）、体脂百分比（F%）、脂肪量（FM）和去脂体重（FFM）评估。测量腰围，并根据血常规计算中性粒细胞、血小板和淋巴细胞计数及中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）和全身免疫炎症指数（SII）。采用 Number Cruncher Statistical System 2007 对数据进行分析。

结果

335 名受试者中，203 名（60.6%）为女孩，132 名（39.4%）为男孩。对女孩进行单因素分析显示，BMI、F%、FM、FFM 和 WC 对 NLR 有影响。FM 仍然是 NLR 的显著独立危险因素（p<0.01）。多元模型中 BMI、F%、FFM 和 WC 的影响无统计学意义（p>0.05）。对女孩进行单因素分析还显示，BMI、F%、FM、FFM 和 WC 对 SII 有影响。F%仍然是 SII 的显著独立危险因素（p<0.01）。多元模型中 BMI、脂肪量、FFM 和 WC 的影响无统计学意义（p>0.05）。