Chen Chenchun, Tang Peng, Zhu Wei
Institute of Public Health, Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, China.
Sci Rep. 2025 Feb 4;15(1):4205. doi: 10.1038/s41598-025-88015-2.
The weight-adjusted waist index (WWI) has emerged as a reliable indicator of abdominal obesity. α-Klotho, a transmembrane protein, functions as a suppressor of aging. However, the relationship between these two factors remains underexplored. This study aims to investigate the association between WWI and serum α-Klotho levels in middle-aged and elderly Americans, with a focus on exploring the potential mediating role of the systemic immune inflammation index (SII). A cross-sectional study was conducted using data from 6997 middle-aged and elderly Americans participating in the National Health and Nutrition Examination Surveys (NHANES) between 2011 and 2016. Multiple linear regression analysis was employed to assess the relationship between WWI and serum α-Klotho concentrations. Additionally, mediation analysis was performed to investigate the mediating effect of SII on the relationships. Our analysis revealed a significant negative correlation between WWI and serum α-Klotho levels in the survey-weighted multiple linear regression models (adjusted percent change: -7.79; 95% CI: -10.15, -5.37). Mediation analysis demonstrated that the association between WWI and α-Klotho levels was partially mediated by SII (adjusted percent change: -0.88; 95% CI: -1.24, -0.45), with the proportion of mediation amounting to 11.6%. Further age-stratified results showed that the mediating role of SII was more pronounced among individuals aged ≥ 60 years, exhibiting a mediating effect of 26.3%, in contrast to 4.2% for those < 60 years. The findings suggest that WWI is inversely associated with serum α-Klotho concentrations and that this association is partially mediated by SII, especially in older people.
体重调整腰围指数（WWI）已成为腹部肥胖的可靠指标。α-klotho是一种跨膜蛋白，具有抗衰老作用。然而，这两个因素之间的关系仍未得到充分探索。本研究旨在调查美国中老年人WWI与血清α-klotho水平之间的关联，重点是探讨全身免疫炎症指数（SII）的潜在中介作用。使用2011年至2016年期间参与美国国家健康与营养检查调查（NHANES）的6997名美国中老年人的数据进行了一项横断面研究。采用多元线性回归分析评估WWI与血清α-klotho浓度之间的关系。此外，进行中介分析以研究SII对这些关系的中介作用。我们的分析显示，在调查加权多元线性回归模型中，WWI与血清α-klotho水平之间存在显著负相关（调整百分比变化：-7.79；95%CI：-10.15，-5.37）。中介分析表明，WWI与α-klotho水平之间的关联部分由SII介导（调整百分比变化：-0.88；95%CI：-1.24，-0.45），中介比例为11.6%。进一步的年龄分层结果显示，SII的中介作用在≥60岁的个体中更为明显，中介效应为26.3%，而<60岁的个体为4.2%。研究结果表明，WWI与血清α-klotho浓度呈负相关，且这种关联部分由SII介导，尤其是在老年人中。
