Furuncuoğlu Y, Tulgar S, Dogan A N, Cakar S, Tulgar Y K, Cakiroglu B
Department of Internal Medicine, Bahcesehir University Faculty of Medicine; Medicalpark Hospital, Istanbul, Turkey.
Eur Rev Med Pharmacol Sci. 2016 Apr;20(7):1300-6.
Obesity is an important preventable cause of death and is a major risk factor for cardiovascular diseases as well as skeletal system diseases and malignancies. In many studies, complete blood count (CBC) and ratios derived from its results - such as the neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and systemic immune inflammatory index have been associated with some diseases and their surveys. In these studies, the body mass index (BMI) and state of obesity of patients and the possible effects of these factors on CBC have not been defined. In this study, our aim was to evaluate the effect of BMI and smoking on CBC and ratios derived from CBC.
In this cross-sectional, retrospective study; the data of male and female patients aged between 18-65 years who presented for a routine check-up or obesity was collected and subjects were grouped as normal weight, overweight, obese and morbidly obese accordingly BMI. Persons' smoking habits were calculated as pack/years. All complete blood count results were noted. Smoking status and BMI groups were compared to CBC findings and ratios derived from these findings.
After exclusion, 223 participants' data (104 female and 119 male) was included in the study. BMI was found to have a statistically significant positive linear correlation with lymphocyte number, PDW, SII and RDW (p < 0.05), and an extremely significant positive linear correlation (p < 0.01) was found between BMI and WBC, neutrophil count, PCT and platelet count. When BMI was not considered and 135 smokers were compared to 88 non-smokers, leukocytes and neutrophil counts were found to be higher in smokers (p < 0.05).
Our study has found that WBC, neutrophil count, lymphocyte count, platelet count, PCT, PDW and SII are significantly affected by BMI status. Future studies that use these parameters and indices must take the participants' BMI and smoking status into account.
肥胖是一个重要的可预防的死亡原因，是心血管疾病、骨骼系统疾病和恶性肿瘤的主要危险因素。在许多研究中，全血细胞计数（CBC）及其结果得出的比率——如中性粒细胞/淋巴细胞比率、血小板/淋巴细胞比率和全身免疫炎症指数，已与一些疾病及其调查相关联。在这些研究中，患者的体重指数（BMI）和肥胖状态以及这些因素对CBC的可能影响尚未明确。在本研究中，我们的目的是评估BMI和吸烟对CBC及其得出的比率的影响。
在这项横断面回顾性研究中，收集了前来进行常规体检或因肥胖就诊的18至65岁男性和女性患者的数据，并根据BMI将受试者分为正常体重、超重、肥胖和病态肥胖组。计算出每人的吸烟习惯为包年数。记录所有全血细胞计数结果。将吸烟状况和BMI组与CBC结果及其得出的比率进行比较。
排除后，223名参与者（104名女性和119名男性）的数据纳入研究。发现BMI与淋巴细胞数量、血小板分布宽度（PDW）、全身免疫炎症指数（SII）和红细胞分布宽度（RDW）呈统计学显著正线性相关（p<0.05），并且发现BMI与白细胞、中性粒细胞计数、降钙素原（PCT）和血小板计数之间存在极显著正线性相关（p<0.01）。在不考虑BMI的情况下，将135名吸烟者与88名非吸烟者进行比较时，发现吸烟者的白细胞和中性粒细胞计数更高（p<0.05）。
我们的研究发现白细胞、中性粒细胞计数、淋巴细胞计数、血小板计数、PCT、PDW和SII受BMI状态的显著影响。使用这些参数和指标的未来研究必须考虑参与者的BMI和吸烟状况。
