RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.
Curr Opin Neurobiol. 2021 Apr;67:106-114. doi: 10.1016/j.conb.2020.10.007. Epub 2020 Nov 4.
Synapses change in strength following patterns of activity, but in many cases seemingly inactive neighbouring synapses also undergo changes in strength. These heterosynaptic changes occur across developmental time-points in various brain circuits in different species, but their precise molecular mechanisms are not well understood. Additionally, heterosynaptic changes can mirror homosynaptic plasticity or occur in opposition to homosynaptic changes. In this review we consider what useful functionality heterosynaptic dynamics could potentially endow the circuit with, and the underlying signalling events that implement heterosynaptic changes. We discuss what unanswered questions remain, and what the future looks like for understanding the logic of synaptic plasticity.
突触会根据活动模式改变强度，但在许多情况下，相邻看似不活跃的突触也会发生强度变化。这些异突触变化发生在不同物种的各种大脑回路的发育时间点，但它们的确切分子机制尚不清楚。此外，异突触变化可以与同突触可塑性一致，也可以与同突触变化相反。在这篇综述中，我们考虑了异突触动力学可能为回路带来的有用功能，以及实现异突触变化的潜在信号事件。我们讨论了仍然存在哪些未解决的问题，以及未来理解突触可塑性逻辑的前景如何。
