RNA 结合蛋白 SRSF1 是免疫系统中基因表达和调控的主要开关。
The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system.
机构信息
Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL, 33431, United States.
Charles E. Schmidt College of Medicine, Florida Atlantic University, 777 Glades Rd, Boca Raton, FL, 33431, United States.
出版信息
Cytokine Growth Factor Rev. 2021 Feb;57:19-26. doi: 10.1016/j.cytogfr.2020.10.008. Epub 2020 Nov 2.
Abstract
Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The aim of this review is to highlight recent findings in the functions of this protein and to describe its role in immune system development, functions and regulation.
摘要
丝氨酸/精氨酸剪接因子 1（SRSF1）是一种在大多数组织中丰富表达的 RNA 结合蛋白。SRSF1 的多效性功能通过调节转录、加工、通过核孔输出和新生 RNA 转录物翻译的主要步骤，在基因表达中发挥多种作用。本文综述的目的是强调该蛋白功能的最新发现，并描述其在免疫系统发育、功能和调节中的作用。
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