全身PET成像在传染病中的应用
Total-Body PET Imaging in Infectious Diseases.
作者信息
Henrich Timothy J, Jones Terry, Beckford-Vera Denis, Price Patricia M, VanBrocklin Henry F
机构信息
Division of Experimental Medicine, University of California San Francisco, 1001 Potrero Avenue, Building 3, Room 525A, San Francisco, CA 94110, USA.
Department of Radiology, University of California Davis Medical Center, Sacramento, CA, USA.
出版信息
PET Clin. 2021 Jan;16(1):89-97. doi: 10.1016/j.cpet.2020.09.011. Epub 2020 Nov 5.
Abstract
Total-body PET enables high-sensitivity imaging with dramatically improved signal-to-noise ratio. These enhanced performance characteristics allow for decreased PET scanning times acquiring data "total-body wide" and can be leveraged to decrease the amount of radiotracer required, thereby permitting more frequent imaging or longer imaging periods during radiotracer decay. Novel approaches to PET imaging of infectious diseases are emerging, including those that directly visualize pathogens in vivo and characterize concomitant immune responses and inflammation. Efforts to develop these imaging approaches are hampered by challenges of traditional imaging platforms, which may be overcome by novel total-body PET strategies.
摘要
全身正电子发射断层扫描（PET）能够实现高灵敏度成像，显著提高信噪比。这些增强的性能特征使得在“全身范围”获取数据时PET扫描时间得以缩短，并且可以利用这一点减少所需放射性示踪剂的用量，从而能够更频繁地进行成像或在放射性示踪剂衰变期间延长成像时间。针对传染病的PET成像新方法正在涌现，包括那些能够在体内直接可视化病原体并表征伴随的免疫反应和炎症的方法。传统成像平台面临的挑战阻碍了这些成像方法的开发工作，而新型全身PET策略或许可以克服这些挑战。
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本文引用的文献
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2
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3
Immunological considerations for COVID-19 vaccine strategies.针对 COVID-19 疫苗策略的免疫学考虑。
Nat Rev Immunol. 2020 Oct;20(10):615-632. doi: 10.1038/s41577-020-00434-6. Epub 2020 Sep 4.
4
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Clinical Course and Molecular Viral Shedding Among Asymptomatic and Symptomatic Patients With SARS-CoV-2 Infection in a Community Treatment Center in the Republic of Korea.韩国社区治疗中心中无症状和有症状的 SARS-CoV-2 感染患者的临床病程和分子病毒脱落情况。
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