Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN 37208-3500, USA.
Department of Pathology, Anatomy and Cell Biology, Meharry Medical College School of Medicine, Nashville General Hospital, Nashville, TN 37208-3599, USA.
Medicina (Kaunas). 2022 Apr 21;58(5):567. doi: 10.3390/medicina58050567.
This article is an overview of guidelines for the clinical diagnosis and surgical treatment of predominantly colonic inflammatory bowel diseases (IBD). This overview describes the systematically and comprehensively multidisciplinary recommendations based on the updated principles of evidence-based literature to promote the adoption of best surgical practices and research as well as patient and specialized healthcare provider education. Colonic IBD represents idiopathic, chronic, inflammatory disorders encompassing Crohn's colitis (CC) and ulcerative colitis (UC), the two unsolved medical subtypes of this condition, which present similarity in their clinical and histopathological characteristics. The standard state-of-the-art classification diagnostic steps are disease evaluation and assessment according to the Montreal classification to enable explicit communication with professionals. The signs and symptoms on first presentation are mainly connected with the anatomical localization and severity of the disease and less with the resulting diagnosis "CC" or "UC". This can clinically and histologically be non-definitive to interpret to establish criteria and is classified as indeterminate colitis (IC). Conservative surgical intervention varies depending on the disease phenotype and accessible avenues. The World Gastroenterology Organizations has, for this reason, recommended guidelines for clinical diagnosis and management. Surgical intervention is indicated when conservative treatment is ineffective (refractory), during intractable gastrointestinal hemorrhage, in obstructive gastrointestinal luminal stenosis (due to fibrotic scar tissue), or in the case of abscesses, peritonitis, or complicated fistula formation. The risk of colitis-associated colorectal cancer is realizable in IBD patients before and after restorative proctocolectomy with ileal pouch-anal anastomosis. Therefore, endoscopic surveillance strategies, aimed at the early detection of dysplasia, are recommended. During the COVID-19 pandemic, IBD patients continued to be admitted for IBD-related surgical interventions. Virtual and phone call follow-ups reinforcing the continuity of care are recommended. There is a need for special guidelines that explore solutions to the groundwork gap in terms of access limitations to IBD care in developing countries, and the irregular representation of socioeconomic stratification needs a strategic plan for how to address this serious emerging challenge in the global pandemic.
本文概述了主要发生于结肠的炎症性肠病(IBD)的临床诊断和外科治疗指南。该概述描述了基于更新的循证文献原则,系统而全面地多学科推荐意见,以促进最佳手术实践和研究的采用,以及患者和专业医疗保健提供者的教育。结肠 IBD 代表特发性、慢性、炎症性疾病,包括克罗恩病结肠炎(CC)和溃疡性结肠炎(UC),这两种未解决的该病医学亚型,其临床和组织病理学特征相似。标准的最先进的分类诊断步骤是根据蒙特利尔分类对疾病进行评估和评估,以实现与专业人员的明确沟通。首次就诊时的症状主要与疾病的解剖定位和严重程度有关,而与导致的诊断“CC”或“UC”关系不大。这在临床上和组织学上难以明确解释以建立标准,并被归类为不确定结肠炎(IC)。保守手术干预取决于疾病表型和可及途径。因此,世界胃肠病组织为临床诊断和管理推荐了指南。当保守治疗无效(难治)、发生难治性胃肠道出血、出现胃肠道腔道狭窄(由于纤维疤痕组织)、或发生脓肿、腹膜炎或复杂瘘管形成时,需要进行手术干预。在进行回肠储袋肛门吻合术的修复性直肠结肠切除术后,IBD 患者存在结直肠癌的风险。因此,建议采用内镜监测策略,旨在早期发现异型增生。在 COVID-19 大流行期间,IBD 患者仍因 IBD 相关手术干预而住院。建议采用虚拟和电话随访,以加强护理的连续性。需要制定特别指南,探讨如何解决发展中国家 IBD 护理受限的基础工作差距问题,以及社会经济分层的代表性不规律问题,需要制定一项战略计划,以应对这一在全球大流行中出现的严重新挑战。