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可作为乳腺癌患者的新型预后生物标志物和治疗靶点。

can serve as novel prognostic biomarker and therapeutic target for Breast Cancer patients.

机构信息

Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.

Department of Operating Room, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, 110004, China.

出版信息

Int J Med Sci. 2020 Sep 30;17(17):2773-2789. doi: 10.7150/ijms.43161. eCollection 2020.

DOI:10.7150/ijms.43161
PMID:33162805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7645343/
Abstract

The role of HCK expression in the prognosis of breast cancer patients is unclear. Thus, this study aimed to explore the clinical implications of HCK expression in breast cancer. We assessed expression and genetic variations in breast cancer using Oncomine, GEPIA, UALCAN, and cBioPortal databases. Then, immunochemistry was used to analyze HCK expression in breast cancer specimens, non-cancer tissues and metastatic cancer tissues. Consequently, we evaluated the effect of HCK expression on survival outcomes set as disease-free survival (DFS) and overall survival (OS). Finally, STRING, Coexpedia, and TISIDB database were explored to identify the molecular functions and regulation pathways of HCK. We found that breast cancer tissues have more mRNA transcripts than non-cancer tissues. Patients with HCK expression had significantly shorter DFS and OS. The ratio of HCK expression was higher in cancer tissues than in non-cancer tissues. These results from STRING database, FunRich software, and TISIDB database showed that HCK was involved in mediating multiple biological processes including immune response-regulating signaling pathway, cell growth and maintenance through multiple signaling pathways including epithelial to mesenchymal transition, PI3K/AKT signaling pathway, and focal adhesion. Overall, may be an oncogene in the development of breast cancer and thus may as a novel biomarker and therapeutic target for breast cancer.

摘要

HCK 表达在乳腺癌患者预后中的作用尚不清楚。因此，本研究旨在探讨 HCK 表达在乳腺癌中的临床意义。我们使用 Oncomine、GEPIA、UALCAN 和 cBioPortal 数据库评估了乳腺癌中的 表达和遗传变异。然后，使用免疫组织化学分析了乳腺癌标本、非癌组织和转移性癌组织中的 HCK 表达。随后，我们评估了 HCK 表达对无病生存（DFS）和总生存（OS）等生存结局的影响。最后，我们使用 STRING、Coexpedia 和 TISIDB 数据库来鉴定 HCK 的分子功能和调控途径。我们发现乳腺癌组织中的 mRNA 转录本多于非癌组织。HCK 表达的患者 DFS 和 OS 显著缩短。癌症组织中 HCK 表达的比例高于非癌组织。来自 STRING 数据库、FunRich 软件和 TISIDB 数据库的这些结果表明，HCK 参与调节多种生物学过程，包括通过上皮间质转化、PI3K/AKT 信号通路和黏附斑等多种信号通路调节免疫反应的信号通路，以及细胞生长和维持。总体而言，HCK 可能是乳腺癌发展中的癌基因，因此可能成为乳腺癌的新型生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/adf2/7645343/9ed42752421f/ijmsv17p2773g010.jpg
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