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新生儿胰腺胰岛细胞坏死：三例报告

Islet cell necrosis in the neonatal pancreas: a report of three cases.

作者信息

Roberts P F

机构信息

Norfolk Hospital, England.

出版信息

J Clin Pathol. 1987 Oct;40(10):1206-11. doi: 10.1136/jcp.40.10.1206.

DOI:10.1136/jcp.40.10.1206
PMID:3316290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1141196/
Abstract

Three cases of islet cell necrosis in neonates are reported. The association of this rare condition with antepartum haemorrhage, anoxia, shock and intravascular coagulation are discussed. The clinical and morphological appearances were compared with previous descriptions of this condition and an association with neonatal hypoglycaemia was made. There are several patho-physiological mechanisms which may be responsible for this unusual pattern of necrosis.

摘要

本文报告了3例新生儿胰岛细胞坏死的病例。讨论了这种罕见病症与产前出血、缺氧、休克及血管内凝血之间的关联。将临床和形态学表现与此前对该病症的描述进行了比较，并发现其与新生儿低血糖有关。有几种病理生理机制可能导致这种不寻常的坏死模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/c00f7fbf5365/jclinpath00330-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/a448272170d3/jclinpath00330-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/dcbc39dbbed4/jclinpath00330-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/c00f7fbf5365/jclinpath00330-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/a448272170d3/jclinpath00330-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/dcbc39dbbed4/jclinpath00330-0061-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99ca/1141196/c00f7fbf5365/jclinpath00330-0063-a.jpg

相似文献

1
Islet cell necrosis in the neonatal pancreas: a report of three cases.新生儿胰腺胰岛细胞坏死：三例报告
J Clin Pathol. 1987 Oct;40(10):1206-11. doi: 10.1136/jcp.40.10.1206.
2
Pancreatic ischaemic lesions without fat necrosis associated with disseminated intravascular coagulation.
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[The endocrine pancreas in neonatal and infantile hyperinsulinaemic hypoglycaemia].[新生儿及婴儿高胰岛素血症性低血糖症中的胰腺内分泌]
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Bilateral ischemic necrosis of the tongue due to disseminated intravascular coagulation.弥散性血管内凝血所致双侧舌缺血性坏死。
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Shock-related injury of pancreatic islets of Langerhans in newborn and young infants.新生儿及幼儿朗格汉斯胰岛的休克相关性损伤。
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[Morphological substrates in the perinatal anoxia syndrome. Intra-alveolar hemorrhage and hyaline membranes of the lung, multiple stomach ulcers, bilateral kidney cortex necroses and periventricular encephalomalacia in a newborn infant].[围产期缺氧综合征的形态学基础。一名新生儿的肺泡内出血、肺透明膜、多发性胃溃疡、双侧肾皮质坏死和脑室周围脑软化]
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[Hemorrhagic necrosis of the marrow in neonatal sepsis complicated by disseminated intravascular coagulation].
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引用本文的文献

1
On the dynamics of the human endocrine pancreas and potential consequences for the development of type 1 diabetes.人类内分泌胰腺的动力学及其对 1 型糖尿病发展的潜在影响。
Acta Diabetol. 2020 Apr;57(4):503-511. doi: 10.1007/s00592-019-01420-8. Epub 2019 Sep 13.

本文引用的文献

1
INVOLUTIONARY CHANGES IN THE ISLETS OF LANGERHANS IN THE FOETUS AND NEWBORN.胎儿及新生儿胰岛的退化性变化
Biol Neonat. 1964;6:16-25. doi: 10.1159/000239884.
2
Renal tubular and pancreatic islet necrosis in newly born infants.新生儿肾小管及胰岛坏死
AMA J Dis Child. 1958 Dec;96(6):705-10. doi: 10.1001/archpedi.1958.02060060707009.
3
Pancreatic isleitis with coxsackie virus B5 infection.伴有柯萨奇病毒B5感染的胰岛炎
Hum Pathol. 1982 Jul;13(7):661-2. doi: 10.1016/s0046-8177(82)80010-5.
4
Pancreatic islet-cell damage in children with fatal viral infections.致命性病毒感染患儿的胰岛细胞损伤
Lancet. 1980 Aug 16;2(8190):354-8.
5
The acute pancreatic effect of alloxan in the rabbit.四氧嘧啶对家兔胰腺的急性作用。
J Endocrinol. 1967 Apr;37(4):421-7. doi: 10.1677/joe.0.0370421.
6
Shock-related injury of pancreatic islets of Langerhans in newborn and young infants.新生儿及幼儿朗格汉斯胰岛的休克相关性损伤。
Hum Pathol. 1985 Dec;16(12):1231-4. doi: 10.1016/s0046-8177(85)80035-6.