Department of Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Front Endocrinol (Lausanne). 2020 Oct 9;11:579909. doi: 10.3389/fendo.2020.579909. eCollection 2020.
Growth hormone (GH) signaling plays a key role in mediating growth, development, metabolism, and lifespan regulation. However, the mechanisms of longevity regulation at the cellular and molecular level are still not well-understood. An important area in the field of GH research is in the development of advanced transgenic systems for conditional expression of GH signaling in a cell type- or tissue-specific manner. There have been many recent studies conducted to examine the effects of tissue-specific GHR disruption. This review updates our previous discussions on this topic and summarizes recent data on the newly-made tissue-specific GHR-KO mice including intestinal epithelial cells, bone, hematopoietic stem cells, cardiac myocytes, and specific brain regions. The data from these new genetically-engineered mice have a significant impact on our understanding of the local GH signaling function.
生长激素（GH）信号在介导生长、发育、代谢和寿命调节中起着关键作用。然而，细胞和分子水平上的长寿调节机制仍不清楚。GH 研究领域的一个重要领域是开发先进的转基因系统，以在细胞类型或组织特异性的方式下条件表达 GH 信号。最近进行了许多研究来研究组织特异性 GHR 破坏的影响。本综述更新了我们之前对此主题的讨论，并总结了最近关于新的组织特异性 GHR-KO 小鼠的数据，包括肠上皮细胞、骨骼、造血干细胞、心肌细胞和特定脑区。这些新的基因工程小鼠的数据对我们理解局部 GH 信号功能有重大影响。
