Peng Jiangling, Yi Jiamin, Yang Wenping, Ren Jingjing, Wen Yuan, Zheng Haixue, Li Dan
State Key Laboratory of Veterinary Etiological Biology, OIE/National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Front Microbiol. 2020 Oct 9;11:2046. doi: 10.3389/fmicb.2020.02046. eCollection 2020.
Foot-and-mouth disease (FMD) is a highly contagious disease that affects cloven-hoofed animals such as pigs, cattle, and sheep. The disease is caused by the foot-and-mouth disease virus (FMDV) which has a non-enveloped virion with icosahedral symmetry that encapsulates a positive-sense, single-stranded RNA genome of ∼8.4 kb. FMDV infection causes obvious immunosuppressive effects on the host. In recent years, studies on the immunosuppressive mechanism of FMDV have become a popular topic. In addition, studies have shown that many FMDV proteins are involved in the regulation of host innate immunity and have revealed mechanisms by which FMDV proteins mediate host innate immunity. In this review, advances in studies on the mechanisms of interaction between FMDV proteins and host innate immunity are summarized to provide a comprehensive understanding of FMDV pathogenesis and the theoretical basis for FMD prevention and control.
口蹄疫（FMD）是一种高度传染性疾病，可感染猪、牛和羊等偶蹄动物。该疾病由口蹄疫病毒（FMDV）引起，其病毒粒子无包膜，呈二十面体对称，包裹着一个约8.4 kb的正链单链RNA基因组。FMDV感染对宿主具有明显的免疫抑制作用。近年来，关于FMDV免疫抑制机制的研究已成为热门话题。此外，研究表明，许多FMDV蛋白参与宿主固有免疫的调节，并揭示了FMDV蛋白介导宿主固有免疫的机制。在本综述中，总结了FMDV蛋白与宿主固有免疫相互作用机制的研究进展，以全面了解FMDV的发病机制，并为FMD的预防和控制提供理论依据。
