Commonwealth Scientific and Industrial Research Organisation (CSIRO) Australian Centre for Disease Preparedness, Geelong, VIC, Australia.
Front Immunol. 2024 Jul 19;15:1397780. doi: 10.3389/fimmu.2024.1397780. eCollection 2024.
Enhancing livestock biosecurity is critical to safeguard the livelihoods of farmers, global and local economies, and food security. Vaccination is fundamental to the control and prevention of exotic and endemic high-priority infectious livestock diseases. Successful implementation of vaccination in a biosecurity plan is underpinned by a strong understanding of correlates of protection-those elements of the immune response that can reliably predict the level of protection from viral challenge. While correlates of protection have been successfully characterized for many human viral vaccines, for many high-priority livestock viral diseases, including African swine fever and foot and mouth disease, they remain largely uncharacterized. Current literature provides insights into potential correlates of protection that should be assessed during vaccine development for these high-priority mammalian livestock viral diseases. Establishment of correlates of protection for biosecurity purposes enables immune surveillance, rationale for vaccine development, and successful implementation of livestock vaccines as part of a biosecurity strategy.
加强牲畜生物安全对于保障农民生计、全球和地方经济以及粮食安全至关重要。疫苗接种是控制和预防外来和地方性高优先级传染性牲畜疾病的基础。在生物安全计划中成功实施疫苗接种的基础是对保护相关因素的深入了解，即免疫反应中的那些可以可靠预测免受病毒挑战的保护水平的因素。虽然已经成功地对许多人类病毒疫苗的保护相关因素进行了描述，但对于许多高优先级的牲畜病毒疾病，包括非洲猪瘟和口蹄疫，它们在很大程度上仍未得到描述。目前的文献提供了对这些高优先级哺乳动物牲畜病毒疾病疫苗开发过程中应进行评估的潜在保护相关因素的见解。为生物安全目的建立保护相关因素，可以实现免疫监测、疫苗开发的合理性以及牲畜疫苗作为生物安全策略的一部分的成功实施。
