Ben Zaken Sara, Radomysky Zorian, Koren Gideon
Adelson School of Medicine, Ariel University, Ariel, Israel.
Maccabi Health Services, Ariel, Israel.
J Alzheimers Dis Rep. 2020 Sep 28;4(1):399-404. doi: 10.3233/ADR-200220.
High magnesium intake has been associated with a decreased risk of dementia. In contrast, other research has found that both low and high serum magnesium levels were associated with an increased risk of Alzheimer's disease and mixed dementia. Hence, presently the role of magnesium levels in dementia is unclear.
To investigate a possible association between serum magnesium concentrations and dementia in a large population-based sample.
Maccabi Healthcare Service in Israel provides healthcare to over 2 million citizens. Maccabi maintains a registry with approximately 26,000 diagnosed dementia patients. We focused on patients of both sexes with Alzheimer's disease or mixed dementia aged 65 or older, excluding patients with clinical diagnoses that could affect serum magnesium level, or with other causes of cognitive decline. Our control group consisted of patients of the same age and sex without dementia.
No significant differences were found in mean, mode, and median magnesium levels between the dementia and control groups. However, there were marginally but significantly more cases with low magnesium levels among dementia patients than among controls: A total of 9.4% of tests done in patients with dementia and 7.81% done in non-dementia subjects were hypomagnesemic ( < 0.00001).
Despite similar means and medians of serum magnesium in dementia and controls, the proportion of lower than normal magnesium test results was slightly higher among dementia patients. It is possible that patients with dementia have more episodes of hypomagnesemia than controls, despite similar overall mean levels of magnesium.
高镁摄入量与痴呆风险降低有关。相比之下，其他研究发现血清镁水平过低和过高均与阿尔茨海默病及混合型痴呆风险增加有关。因此，目前镁水平在痴呆中的作用尚不清楚。
在一个基于人群的大样本中研究血清镁浓度与痴呆之间可能存在的关联。
以色列的马卡比医疗服务机构为超过200万公民提供医疗服务。马卡比维护着一个约有26000名已确诊痴呆患者的登记册。我们重点关注年龄在65岁及以上的患有阿尔茨海默病或混合型痴呆的男女患者，排除那些临床诊断可能影响血清镁水平或存在其他认知衰退原因的患者。我们的对照组由年龄和性别相同但无痴呆的患者组成。
痴呆组和对照组在镁水平的均值、众数和中位数方面未发现显著差异。然而，痴呆患者中镁水平低的病例略多于对照组，但差异具有统计学意义：痴呆患者中共有9.4%的检测结果为低镁血症（<0.00001），非痴呆受试者中这一比例为7.81%。
尽管痴呆患者和对照组的血清镁均值和中位数相似，但痴呆患者中低于正常镁检测结果的比例略高。尽管总体镁平均水平相似，但痴呆患者可能比对照组有更多低镁血症发作。
