Lu Xiujuan, Guo Xinhao, Wan Dong, Pan Jie
School of Chemistry and Chemical Engineering, Tiangong University, Tianjin 300387, China.
Sheng Wu Gong Cheng Xue Bao. 2020 Sep 25;36(9):1723-1731. doi: 10.13345/j.cjb.190586.
In order to achieve better tumor treatment, researchers have designed dual and multiple responsive smart nanocarriers in the tumor microenvironment. Among them, the research based on acid-sensitive dual-responsive nanocarriers is the most extensive and common one. Intelligent nanocarriers have initially achieved long circulation in body, effective accumulation in tumor cells, and controlled drug release in tumor microenvironment, with increased anti-tumor effect of drug and reduced damage to normal tissues. However, there are still many problems to be solved in current research, such as high price, complicated nanocarriers structure, and unclear mechanisms of drug delivery in the body, all hampering nanocarriers from clinical applications. This article introduces the progress of nanocarriers in recent years from the dual responsive aspects including acid-temperature, acid-magnetism, acid-redox, acid-enzyme, acid-light and acid-ultrasound, to provide reference for further clinical application of nanomedicine.
为了实现更好的肿瘤治疗效果，研究人员在肿瘤微环境中设计了双响应和多响应智能纳米载体。其中，基于酸敏双响应纳米载体的研究最为广泛和常见。智能纳米载体最初已在体内实现了长循环、在肿瘤细胞中有效蓄积以及在肿瘤微环境中实现可控药物释放，提高了药物的抗肿瘤效果并减少了对正常组织的损伤。然而，当前研究仍存在许多有待解决的问题，如价格高昂、纳米载体结构复杂以及体内药物递送机制不明等，所有这些都阻碍了纳米载体的临床应用。本文从酸-温度、酸-磁、酸-氧化还原、酸-酶、酸-光和酸-超声等双响应方面介绍了近年来纳米载体的研究进展，为纳米医学的进一步临床应用提供参考。
