急性髓性白血病细胞中白细胞介素1β的自分泌刺激
Autocrine stimulation of interleukin 1 beta in acute myelogenous leukemia cells.
作者信息
Sakai K, Hattori T, Matsuoka M, Asou N, Yamamoto S, Sagawa K, Takatsuki K
机构信息
Second Department of Internal Medicine, Kumamoto University Medical School, Japan.
出版信息
J Exp Med. 1987 Nov 1;166(5):1597-602. doi: 10.1084/jem.166.5.1597.
Abstract
A significant increase in CD25 antigen-positive cells by IL-1 was observed in cells of a patient with M7 acute myelogenous leukemia. Basal proliferation and expression of CD25 antigen by the M7 leukemic cells were inhibited by addition of anti-IL-1 beta antibody in a dose-dependent manner, but not by rabbit anti-IL-1 alpha antibody. Culture supernatants of these leukemic cells contained IL-1 activity, which was specifically inhibited by addition of anti-IL-1 beta antibody, and Northern blot analysis detected intracellular IL-1 beta mRNA. These results indicated that autocrine secretion of IL-1 beta was involved in proliferation of some myelogenous leukemic cells.
摘要
在一名M7型急性髓性白血病患者的细胞中，观察到IL-1使CD25抗原阳性细胞显著增加。添加抗IL-1β抗体可剂量依赖性抑制M7白血病细胞的基础增殖和CD25抗原表达，但兔抗IL-1α抗体无此作用。这些白血病细胞的培养上清液含有IL-1活性，添加抗IL-1β抗体可特异性抑制该活性，Northern印迹分析检测到细胞内IL-1β mRNA。这些结果表明，IL-1β的自分泌分泌参与了一些髓性白血病细胞的增殖。
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本文引用的文献
1
The activity of partially purified leukocytic endogenous mediator in endotoxin-resistant C3H/HeJ mice.内毒素耐受的C3H/HeJ小鼠中部分纯化的白细胞内源性介质的活性
J Lab Clin Med. 1980 Apr;95(4):616-23.
2
T-Cell lymphoma model for the analysis of interleukin 1-mediated T-cell activation.用于分析白细胞介素1介导的T细胞活化的T细胞淋巴瘤模型。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1133-7. doi: 10.1073/pnas.78.2.1133.
3
Fluorescent phycobiliprotein conjugates for analyses of cells and molecules.用于细胞和分子分析的荧光藻胆蛋白偶联物。
J Cell Biol. 1982 Jun;93(3):981-6. doi: 10.1083/jcb.93.3.981.
4
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.一种将DNA限制性内切酶片段放射性标记至高比活度的技术。
Anal Biochem. 1983 Jul 1;132(1):6-13. doi: 10.1016/0003-2697(83)90418-9.
5
Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group.急性髓系白血病分类的修订标准建议。法美英协作组报告
Ann Intern Med. 1985 Oct;103(4):620-5. doi: 10.7326/0003-4819-103-4-620.
6
Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.白细胞介素1诱导培养的人内皮细胞产生粒细胞-巨噬细胞集落刺激因子。
J Clin Invest. 1987 Jan;79(1):48-51. doi: 10.1172/JCI112806.
7
Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in acute myeloblastic leukemia.粒细胞-巨噬细胞集落刺激因子基因在急性髓细胞白血病中的组成性表达。
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9
The human hematopoietic colony-stimulating factors.人类造血集落刺激因子
Science. 1987 Jun 5;236(4806):1229-37. doi: 10.1126/science.3296190.
10
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Cell. 1986 Jun 6;45(5):667-74. doi: 10.1016/0092-8674(86)90781-6.
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