Chui H C
Department of Neurology, University of Southern California, School of Medicine, Los Angeles.
J Neural Transm Suppl. 1987;24:57-68.
The significance of clinically defined subgroups of Alzheimer's disease (AD) is discussed within a framework of etiologic, pathogenetic, and treatment issues. Cerebral amyloid angiopathy and familial AD are proposed as etiologic subtypes. Clinical heterogeneity associated with age at onset and sex are thought to reflect the presence of secondary pathogenetic factors. Longitudinal studies are necessary to clarify the meaning of various symptomatic patterns.
在病因、发病机制和治疗问题的框架内，讨论了阿尔茨海默病（AD）临床定义亚组的意义。脑淀粉样血管病和家族性AD被提出作为病因亚型。与发病年龄和性别相关的临床异质性被认为反映了继发性发病因素的存在。需要进行纵向研究以阐明各种症状模式的意义。
