Department of Hepatobiliary and Pancreatic Surgery, University Hospitals of Leicester NHS Trust, Gwendolen Road, Leicester, LE5 4PW, UK.
Discipline of Surgery, The Queen Elizabeth Hospital, University of Adelaide, Adelaide, SA, Australia.
World J Surg. 2021 Feb;45(2):590-597. doi: 10.1007/s00268-020-05828-0. Epub 2020 Nov 9.
Malnutrition is a common sequela of chronic pancreatitis (CP). Alterations in body composition and the assessment of sarcopenia have gained the interest of clinicians in recent years. There is a scarcity of data currently available concerning sarcopenia in patients with CP. This review aims to investigate the prevalence and impact of sarcopenia in CP.
Embase and Medline databases were used to identify all studies that evaluated sarcopenia and outcomes in patients with chronic pancreatitis. Due to paucity of data, conference abstracts were included. PRISMA guidelines for systematic reviews were followed.
Six studies, with a total of 450 individuals were reviewed. Three full-text studies and three conference abstracts met the predetermined eligibility criteria. The prevalence of sarcopenia in CP from all studies ranged from 17-62%. Pancreatic exocrine insufficiency was associated as an independent and significant risk factor for sarcopenia. Sarcopenia was found to be associated with a reduced quality of life, increased hospitalisation, and reduced survival. It was associated with significantly lower islet yield following total pancreatectomy with islet auto transplantation in CP.
The review of these existing studies amalgamates the limited data on sarcopenia and its impact on CP. It has shown that sarcopenia is exceedingly prevalent and an important risk factor in CP patients. The data presented emphasises that sarcopenia has a significant prognostic value and should be included in future prospective analyses in the outcomes of CP.
营养不良是慢性胰腺炎（CP）的常见后遗症。近年来，身体成分的改变和肌少症的评估引起了临床医生的兴趣。目前关于 CP 患者肌少症的数据稀缺。本综述旨在探讨 CP 中肌少症的患病率和影响。
使用 Embase 和 Medline 数据库来确定所有评估慢性胰腺炎患者肌少症和结局的研究。由于数据匮乏，会议摘要也被纳入其中。本综述遵循 PRISMA 系统评价指南。
共回顾了 6 项研究，总计 450 人。3 项全文研究和 3 项会议摘要符合预定的入选标准。所有研究中 CP 肌少症的患病率从 17%-62%不等。胰腺外分泌功能不全被认为是肌少症的独立且重要的危险因素。肌少症与生活质量下降、住院增加和生存率降低有关。在 CP 患者中进行全胰切除术伴胰岛自体移植时，肌少症与胰岛产量显著降低有关。
对这些现有研究的综述汇总了关于肌少症及其对 CP 影响的有限数据。结果表明，肌少症在 CP 患者中非常普遍，是一个重要的危险因素。所呈现的数据强调了肌少症具有重要的预后价值，应该包含在 CP 结局的未来前瞻性分析中。
