Kilic Gizem Seray, Tahtaci Mustafa, Yagmur Funda, Akin Fatma Ebru, Tayfur Yurekli Oyku, Ersoy Osman
Department of Internal Medicine, Kusadasi State Hospital, Aydin, Turkey.
Department of Gastroenterology, Faculty of Medicine, Ankara Yildirim Beyazit University, Ankara, Turkey.
Medicine (Baltimore). 2024 Dec 6;103(49):e40868. doi: 10.1097/MD.0000000000040868.
Sarcopenia can be defined as the loss of muscle mass and strength. It is a poor prognostic factor for many diseases. Our study aims to assess the prevalence of sarcopenia in patients with acute pancreatitis using bioelectrical impedance analysis (BIA) and hand dynamometry while also investigating its impact on acute pancreatitis. Sixty patients admitted with a diagnosis of acute pancreatitis were included in this prospective study. Following their admissions, prognostic markers were calculated, muscle strengths were measured using a hand dynamometer, and body compositions were determined using a BIA device. Accordingly, acute pancreatitis patients were divided into 2 groups: sarcopenic and nonsarcopenic. The demographic characteristics, anthropometric measurements, Ranson score, Glasgow-Imrie score, Balthazar score, APACHE-II score, disease severity according to the Atlanta classification, length of hospital stay, and laboratory findings of the 2 groups were compared. Sarcopenia was identified in 11 cases among those with acute pancreatitis included in the study. In the sarcopenic group, the mean age, Glasgow-Imrie score and number of cases with severe acute pancreatitis according to the Atlanta classification were significantly higher; body mass index, upper arm circumference, skeletal muscle mass index, and grip strength were significantly lower (P < .05). This study is the first to evaluate sarcopenia in acute pancreatitis cases using BIA and hand dynamometry. Sarcopenia may play a significant role in predicting the prognosis of acute pancreatitis.
肌肉减少症可定义为肌肉质量和力量的丧失。它是许多疾病的不良预后因素。我们的研究旨在使用生物电阻抗分析（BIA）和握力测量法评估急性胰腺炎患者中肌肉减少症的患病率，同时研究其对急性胰腺炎的影响。本前瞻性研究纳入了60例诊断为急性胰腺炎的患者。入院后，计算预后指标，使用握力计测量肌肉力量，并使用BIA设备测定身体成分。据此，将急性胰腺炎患者分为两组：肌肉减少症组和非肌肉减少症组。比较了两组的人口统计学特征、人体测量学指标、兰森评分、格拉斯哥-因米里评分、巴尔萨泽评分、急性生理与慢性健康状况评分系统II（APACHE-II）评分、根据亚特兰大分类法的疾病严重程度、住院时间和实验室检查结果。在纳入研究的急性胰腺炎患者中，有11例被确定为肌肉减少症。在肌肉减少症组中，平均年龄、格拉斯哥-因米里评分以及根据亚特兰大分类法诊断为重症急性胰腺炎的病例数显著更高；体重指数、上臂围、骨骼肌质量指数和握力显著更低（P < 0.05）。本研究首次使用BIA和握力测量法评估急性胰腺炎病例中的肌肉减少症。肌肉减少症可能在预测急性胰腺炎的预后中起重要作用。
