Elibol Rahmi, Şengör Neslihan Serap
Electronics and Communication Engineering, Istanbul Technical University, Istanbul, Turkey.
Engineering Faculty, Erzincan University, Erzincan, Turkey.
J Comput Neurosci. 2021 Feb;49(1):21-35. doi: 10.1007/s10827-020-00769-y. Epub 2020 Nov 9.
Nucleus accumbens is part of the neural structures required for reward based learning and cognitive processing of motivation. Understanding its cellular dynamics and its role in basal ganglia circuits is important not only in diagnosing behavioral disorders and psychiatric problems as addiction and depression but also for developing therapeutic treatments for them. Building a computational model would expand our comprehension of nucleus accumbens. In this work, we are focusing on establishing a model of nucleus accumbens which has not been considered as much as dorsal striatum in computational neuroscience. We will begin by modeling the behavior of single cells and then build a holistic model of nucleus accumbens considering the effect of synaptic currents. We will verify the validity of the model by showing the consistency of simulation results with the empirical data. Furthermore, the simulation results reveal the joint effect of cortical stimulation and dopaminergic modulation on the activity of medium spiny neurons. This effect differentiates with the type of dopamine receptors.
伏隔核是基于奖励的学习和动机认知处理所需神经结构的一部分。了解其细胞动力学及其在基底神经节回路中的作用不仅对于诊断行为障碍和成瘾、抑郁等精神问题很重要，而且对于开发针对这些问题的治疗方法也很重要。构建一个计算模型将扩展我们对伏隔核的理解。在这项工作中，我们专注于建立一个伏隔核模型，该模型在计算神经科学中没有像背侧纹状体那样受到足够的关注。我们将首先对单个细胞的行为进行建模，然后考虑突触电流的影响构建一个伏隔核的整体模型。我们将通过展示模拟结果与经验数据的一致性来验证模型的有效性。此外，模拟结果揭示了皮层刺激和多巴胺能调制对中等棘状神经元活动的联合作用。这种作用因多巴胺受体类型而异。
