Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2021 Jan;133:110986. doi: 10.1016/j.biopha.2020.110986. Epub 2020 Nov 7.
Phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor protein which is altered in several malignancies. This protein is a negative regulator of the PI3K/AKT signaling. Several transcription factors regulate the expression of PTEN in positive or negative directions. Moreover, numerous microRNAs (miRNAs) have functional interactions with PTEN and inhibit its expression. Suppression of PTEN can attenuate the response of cancer cells to chemotherapeutic agents. Based on the critical role of this tumor suppressor gene, the identification of negative regulators of its expression has practical significance particularly in the prevention and management of cancer. Meanwhile, the interaction between miRNAs and PTEN has functional consequences in non-malignant disorders including myocardial infarction, osteoporosis, cerebral ischemic stroke, and recurrent abortion. In the present review, we describe the role of miRNAs in the regulation of expression and activity of PTEN.
磷酸酶和张力蛋白同源物（PTEN）基因编码一种肿瘤抑制蛋白，该蛋白在多种恶性肿瘤中发生改变。该蛋白是 PI3K/AKT 信号的负调节剂。有几种转录因子正向或负向调节 PTEN 的表达。此外，许多 microRNAs（miRNAs）与 PTEN 具有功能相互作用并抑制其表达。PTEN 的抑制可减弱癌细胞对化疗药物的反应。鉴于该肿瘤抑制基因的关键作用，鉴定其表达的负调控因子具有重要的实际意义，特别是在癌症的预防和管理方面。同时，miRNAs 与 PTEN 之间的相互作用在非恶性疾病中具有功能后果，包括心肌梗死、骨质疏松症、脑缺血性中风和复发性流产。在本综述中，我们描述了 miRNAs 在调节 PTEN 的表达和活性中的作用。
