Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, United Kingdom.
Institute of Chemistry, São Paulo State University (UNESP), 14800-060, Araraquara, São Paulo, Brazil.
Biosens Bioelectron. 2021 Jan 15;172:112705. doi: 10.1016/j.bios.2020.112705. Epub 2020 Oct 22.
In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.
在这项工作中，我们证明了一种基于阻抗的电容测量方法能够清晰地分辨出受电极限制的聚合物薄膜的共振电导特性。通过在薄膜上修饰受体，这种电导可以通过特定目标的捕获来调节，本文以 C-反应蛋白为例进行了演示。这种无需试剂且单步标记定量的方法与将检测方法向需要最小用户干预的可扩展格式推进的趋势是相关的。
