School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan.
Department of Speech Language Pathology & Audiology, Chung Shan Medical University, Taichung 40201, Taiwan.
Cells. 2020 Nov 5;9(11):2417. doi: 10.3390/cells9112417.
Unilateral vocal fold paralysis (UVFP) is a common disorder that may cause glottal closure insufficiency and then hoarseness of voice and aspiration during swallowing. We conducted a systematic review and meta-analysis to evaluate whether hyaluronic acid (HA) injection laryngoplasty (IL) is an effective treatment for patients with UVFP. Comprehensive systematic searches were undertaken using PubMed, EBSCO Medline, and Cochrane Library databases. We appraised the quality of studies according to preset inclusion and exclusion criteria. The lengths of follow-up were divided into "short-term" (3 months or shorter), "medium-term" (6 months), and "long-term" (12 months or longer). We performed random-effect meta-analysis to estimate the changes in voice-related quality of life, perceptual evaluation by grading systems, voice lab analysis of maximal phonation time, and normalized glottal gap area, before and after HA IL. Fourteen studies were eligible for the final analysis. The results showed that patients' glottal closure insufficiency could be improved; maximal phonation time could be prolonged; perceptual evaluations of the voice and quality of life were better after HA IL, but the duration of treatment effect varied among different studies. In conclusion, HA IL is an effective treatment for UVFP, which may achieve a long-term effect and therefore reduce the likelihood of requiring permanent medialization thyroplasty.
单侧声带麻痹（UVFP）是一种常见疾病，可能导致声门关闭不全，继而出现声音嘶哑和吞咽时误吸。我们进行了系统评价和荟萃分析，以评估透明质酸（HA）注射喉成形术（IL）是否是治疗单侧声带麻痹患者的有效方法。使用 PubMed、EBSCO Medline 和 Cochrane Library 数据库进行全面的系统检索。我们根据预设的纳入和排除标准评估研究质量。随访时间分为“短期”（3 个月或更短）、“中期”（6 个月）和“长期”（12 个月或更长）。我们进行随机效应荟萃分析，以估计 HA IL 前后声音相关生活质量、分级系统的听觉评估、最大发声时间的语音分析以及正常化声门裂面积的变化。14 项研究符合最终分析的条件。结果表明，患者的声门关闭不全可以得到改善；最大发声时间可以延长；HA IL 后声音和生活质量的听觉评估更好，但治疗效果的持续时间在不同研究中有所不同。总之，HA IL 是治疗单侧声带麻痹的有效方法，可能具有长期效果，因此减少了对永久性声带内移术的需求。
