Department of Otolaryngology Head and Neck Surgery, Istanbul University-Cerrahpasa Cerrahpasa Medical Faculty, Istanbul, Turkey.
Department of Audiology, İstanbul University-Cerrahpasa School of Health Science, İstanbul, Turkey.
Ann Otol Rhinol Laryngol. 2024 May;133(5):524-531. doi: 10.1177/00034894241232478. Epub 2024 Feb 20.
This study was conducted to present the long-term functional outcomes of injection laryngoplasty (IL) with hyaluronic acid/dextranomer (HA/D) in unilateral vocal fold paralysis (UVFP).
A total of 40 patients who underwent HA/D injection for UVFP were enrolled. The acoustic analysis of the voice was evaluated with jitter percentage, shimmer percentage, maximum phonation time, harmonics-to-noise ratio, and fundamental frequency. The psychosocial effect of the voice was determined using the Voice Handicap Index-10. Fiberoptic endoscopic evaluation of swallowing was performed and 2 scales were used for quantification: a modified penetration-aspiration scale and a dysphagia score. All measurements were performed at preoperative day and postoperative months 1, 6, and 24.
A statistically significant improvement was observed for all of the evaluated parameters except the maximum phonation time for postoperative months 1, 6, and 24 ( < .05). In the evaluation of the maximum phonation time, although there was a significant improvement for the postoperative months 1 and 6, no significant difference was observed between the postoperative 24th month and the preoperative value.
HA/D injection laryngoplasty is an effective method both in the short- and long-term to improve voice and swallowing functions in patients with UVFP.
本研究旨在展示透明质酸/葡聚糖（HA/D）注射喉成形术（IL）治疗单侧声带麻痹（UVFP）的长期功能结果。
共纳入 40 例因单侧声带麻痹而接受 HA/D 注射的患者。通过抖动百分比、闪烁百分比、最长发声时间、谐噪比和基频对嗓音的声学分析进行评估。使用嗓音障碍指数-10 来确定嗓音的社会心理影响。进行纤维内镜吞咽评估，并使用 2 个量表进行量化：改良渗透-吸入量表和吞咽困难评分。所有测量均在术前第 1 天和术后第 1、6 和 24 个月进行。
除术后第 1、6 和 24 个月的最长发声时间外（ < .05），所有评估参数均观察到统计学显著改善。在最长发声时间的评估中，尽管术后第 1 个月和第 6 个月有显著改善，但与术前值相比，术后第 24 个月无显著差异。
HA/D 注射喉成形术是一种有效的方法，无论是在短期还是长期内，都可以改善单侧声带麻痹患者的嗓音和吞咽功能。
