Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia.
Faculty of Pharmacy, Medical University-Sofia, Bul. "Acad. Ivan Geshov" 15, 1000 Sofia, Bulgaria.
Molecules. 2020 Nov 5;25(21):5142. doi: 10.3390/molecules25215142.
is used in herbal medicinal products for the prevention and treatment of the common cold, as well as for skin disorders and minor wounds. In this study, the efficiency of traditional maceration using water and ethanol was compared with the maceration using mixtures of water and glycerol, a non-toxic, biodegradable solvent from renewable sources. It was found that the glycerol-water mixtures were as effective as ethanol/water mixtures for the extraction of caffeic acid derivatives. All the prepared extracts demonstrated notable antiradical properties. Furthermore, an efficient ultrasound-assisted extraction using glycerol-water mixtures was developed using six independent variables. Their levels needed for the maximum extraction of caffeic acid derivatives were as follows: glycerol 90% (), temperature 70 °C, ultrasound power 72 W, time 40 min, and ascorbic acid 0 mg/mL. Under the optimized conditions, ultrasound-assisted extraction was superior to maceration. It achieved significantly higher yields of phenolic acids in shorter extraction time. The presence of zinc in plant material may contribute to the beneficial effects of preparations. Since glycerol is a non-toxic solvent with humectant properties, the prepared extracts can be directly used for the preparation of cosmetics or oral pharmaceutical formulations without the need for solvent removal.
它被用于草药药物中，用于预防和治疗普通感冒，以及用于皮肤疾病和小伤口。在这项研究中，比较了使用水和乙醇的传统浸渍法与使用水和甘油混合物的浸渍法的效率，甘油是一种无毒、可生物降解的可再生资源溶剂。研究发现，甘油-水混合物在提取咖啡酸衍生物方面与乙醇/水混合物一样有效。所有制备的提取物都表现出显著的抗氧化性能。此外，还开发了一种使用甘油-水混合物的高效超声辅助提取方法，使用了六个独立变量。提取咖啡酸衍生物的最大用量如下：甘油 90%（）、温度 70°C、超声功率 72 W、时间 40 分钟和抗坏血酸 0 mg/mL。在优化条件下，超声辅助提取优于浸渍法。它在更短的提取时间内实现了更高的酚酸收率。植物材料中锌的存在可能有助于制剂的有益效果。由于甘油是一种具有保湿特性的无毒溶剂，因此制备的提取物可以直接用于制备化妆品或口服药物制剂，而无需去除溶剂。
