Genetic Markers as Risk Factors for the Development of Impulsive-Compulsive Behaviors in Patients with Parkinson's Disease Receiving Dopaminergic Therapy.

Impulsive-compulsive and related behavioral disorders (ICD) are drug-induced non-motor symptoms of Parkinson's disease (PD). Recently research has focused on evaluating whether ICD could be predicted and managed using a pharmacogenetic approach based on dopaminergic therapies, which are the main risk factors. The aim of our study was to evaluate the role of candidate genes such as , , , , , , , , gene polymorphisms in the pathogenesis of ICD in PD. We compared patients with PD and ICD ( = 49), patients with PD without ICD ( = 36) and a healthy control group ( = 365). ICD was diagnosed using the QUIP questionnaires and specific diagnostic criteria for subtypes of ICD. Genotyping was conducted using a number of PCR techniques and SNaPshot. Statistical analysis was performed using WinPepi and APSampler v3.6 software. PCA testing was conducted using RStudio software v1.4.1106-5. The following substitutions showed statistically significant correlations with PD and ICD: (rs2097629, rs1611115), (rs6275, rs12364283, rs1076560), (rs4646994), (rs686), (rs6265), these associations are novel in Russian PD patients. Our findings suggest that polymorphisms in , , , genes in Russian subjects are associated with an increased risk of ICD development.