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德国肝移植受者移植后护理的当前挑战

Current Challenges in the Post-Transplant Care of Liver Transplant Recipients in Germany.

作者信息

Herzer Kerstin, Sterneck Martina, Welker Martin-Walter, Nadalin Silvio, Kirchner Gabriele, Braun Felix, Malessa Christina, Herber Adam, Pratschke Johann, Weiss Karl Heinz, Jaeckel Elmar, Tacke Frank

机构信息

Department of Gastroenterology and Hepatology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Knappschafts-Klinik Bad Neuenahr, 53474 Bad Neuenahr-Ahrweiler, Germany.

出版信息

J Clin Med. 2020 Nov 5;9(11):3570. doi: 10.3390/jcm9113570.

Abstract

Improving long-term patient and graft survival after liver transplantation (LT) remains a major challenge. Compared to the early phase after LT, long-term morbidity and mortality of the recipients not only depends on complications immediately related to the graft function, infections, or rejection, but also on medical factors such as de novo malignancies, metabolic disorders (e.g., new-onset diabetes, osteoporosis), psychiatric conditions (e.g., anxiety, depression), renal failure, and cardiovascular diseases. While a comprehensive post-transplant care at the LT center and the connected regional networks may improve outcome, there is currently no generally accepted standard to the post-transplant management of LT recipients in Germany. We therefore described the structure and standards of post-LT care by conducting a survey at 12 German LT centers including transplant hepatologists and surgeons. Aftercare structures and form of cost reimbursement considerably varied between LT centers across Germany. Further discussions and studies are required to define optimal structure and content of post-LT care systems, aiming at improving the long-term outcomes of LT recipients.

摘要

提高肝移植(LT)后患者和移植物的长期存活率仍然是一项重大挑战。与肝移植后的早期阶段相比,受者的长期发病率和死亡率不仅取决于与移植物功能、感染或排斥反应直接相关的并发症,还取决于诸如新发恶性肿瘤、代谢紊乱(如新发糖尿病、骨质疏松症)、精神疾病(如焦虑、抑郁)、肾衰竭和心血管疾病等医学因素。虽然肝移植中心及相关区域网络提供的全面移植后护理可能会改善预后,但目前德国对于肝移植受者的移植后管理尚无普遍接受的标准。因此,我们通过对德国12个肝移植中心(包括移植肝病学家和外科医生)进行调查,描述了肝移植后护理的结构和标准。德国各肝移植中心的随访护理结构和费用报销形式差异很大。需要进一步的讨论和研究来确定肝移植后护理系统的最佳结构和内容,以改善肝移植受者的长期预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93d9/7694452/93f718d306ad/jcm-09-03570-g001.jpg

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