Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha 410008, China.
Mini Rev Med Chem. 2021;21(5):554-575. doi: 10.2174/1389557520666201109120855.
Rhein, an anthraquinone derivative, has been employed widely, especially for the treatment of intractable diseases like diabetic nephropathy, arthritis, and cancer in a unique action mechanism. In the last decades, considerable efforts have been made in structural modification of rhein. This paper reviewed patents on pharmacological activity and therapeutic application of rhein and its derivatives from 1978 to 2018. Particularly, an analysis of patents was made, with the top 10 most valuable patents presented, and the interpretation of the legal status of patents was given. Given the properties of superior pharmacological activity, rich resources, cheap price, low toxicity, and mature extraction process, it is believed that an in-depth investigation on rhein and its derivatives is worth trying.
大黄酸是蒽醌衍生物的一种，具有独特的作用机制，已被广泛应用于治疗糖尿病肾病、关节炎和癌症等疑难病症。在过去几十年中，人们对大黄酸的结构进行了大量的修饰。本文综述了 1978 年至 2018 年大黄酸及其衍生物的药理学活性和治疗应用的专利。特别地，对专利进行了分析，提出了 10 项最有价值的专利，并对专利的法律地位进行了解释。鉴于大黄酸具有优良的药理学活性、丰富的资源、低廉的价格、低毒性和成熟的提取工艺，相信对大黄酸及其衍生物进行深入研究是值得尝试的。
