关于大黄酸及其衍生物治疗潜力的研究进展。
A research update on the therapeutic potential of rhein and its derivatives.
机构信息
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science, Southern Medical University, Guangzhou, 510515, China.
College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
出版信息
Eur J Pharmacol. 2021 May 15;899:173908. doi: 10.1016/j.ejphar.2021.173908. Epub 2021 Jan 27.
Rhein is one of the anthraquinones components of Rheum. It shows excellent clinical efficacy and is widely used in the management of several disease conditions including tumors, inflammation, diabetic nephropathy, and viral infections. In this review, we summarize the recent studies on the pharmacological activities of rhein and its derivatives, as well as their association with different diseases and possible mechanisms based on our previous review. This review serves as an updated and a supplement to our previous report highlighting the use of rhein in nanotechnology. It also serves as a reference study and offers an overall picture of the use of rhein and its derivatives in nanotechnology.
大黄酸是大黄的蒽醌类成分之一。它具有优异的临床疗效，广泛用于多种疾病的治疗，包括肿瘤、炎症、糖尿病肾病和病毒感染。在这篇综述中，我们总结了大黄酸及其衍生物的药理学活性的最新研究，以及它们与不同疾病的关联和可能的机制，这是基于我们之前的综述。与我们之前关于大黄酸在纳米技术中应用的报告相比，本篇综述是一个更新和补充，强调了大黄酸在纳米技术中的应用。它也作为一个参考研究，提供了大黄酸及其衍生物在纳米技术中的应用的全貌。
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