Barcelona Institute for Global Health (ISGlobal), Hospital Clínic, University of Barcelona, Barcelona, Spain
Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
BMJ Open. 2020 Nov 9;10(11):e039724. doi: 10.1136/bmjopen-2020-039724.
Injecting drug use is the primary driver of hepatitis C virus (HCV) infection in Europe. Despite the need for more engagement with care, people who inject drugs (PWID) are hard to reach with HCV testing and treatment. We initiated a study to evaluate the efficacy for testing and linkage to care among PWID consulting peer-based testing at a mobile clinic in Copenhagen, Denmark.
In this intervention study, we will recruit participants at a single community-based, peer-run mobile clinic. In a single visit, we will first offer participants a point-of-care HCV antibody test, and if they test positive, then they will receive an HCV RNA test. If they are HCV-RNA+, we will administer facilitated referrals to designated 'fast-track' clinics at a hospital or an addiction centre for treatment. The primary outcomes for this study are the number of tested and treated individuals. Secondary outcomes include individuals lost at each step in the care cascade.
The results of this study could provide a model for targeting PWID for HCV testing and treatment in Demark and other settings, which could help achieve WHO HCV elimination targets. The Health Research Ethics Committee of Denmark and the Danish Data Protection Agency confirmed (December 2018/January 2019) that this study did not require their approval. Study findings will be disseminated through peer-reviewed publications, conference presentations and social media.
在欧洲，注射吸毒是丙型肝炎病毒（HCV）感染的主要驱动因素。尽管需要更多地参与护理，但很难接触到注射吸毒者（PWID）进行 HCV 检测和治疗。我们启动了一项研究，以评估在丹麦哥本哈根的一个移动诊所中，基于同伴的检测对 PWID 进行检测和联系护理的效果。
在这项干预研究中，我们将在一个单一的社区为基础的、同伴管理的移动诊所招募参与者。在一次就诊中，我们将首先为参与者提供即时 HCV 抗体检测，如果他们的检测结果呈阳性，我们将为他们提供 HCV RNA 检测。如果他们的 HCV-RNA+，我们将为他们提供便利的转介，转介到医院或戒毒中心的“快速通道”诊所进行治疗。本研究的主要结果是接受检测和治疗的人数。次要结果包括在护理级联的每个步骤中失去的个体。
这项研究的结果可以为丹麦和其他地区针对 PWID 的 HCV 检测和治疗提供一个模式，这有助于实现世卫组织 HCV 消除目标。丹麦卫生研究伦理委员会和丹麦数据保护局（2018 年 12 月/2019 年 1 月）确认，这项研究不需要他们的批准。研究结果将通过同行评议的出版物、会议演讲和社交媒体进行传播。
