Al-Zahrani Jamaan
College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Saudi J Biol Sci. 2021 Jan;28(1):738-743. doi: 10.1016/j.sjbs.2020.11.001. Epub 2020 Nov 5.
Coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has emerged as a fatal pandemic and has crushed even the world's best healthcare systems. Globally, it has affected 40,373,228 individuals and resulted in 1,119,568 deaths as of October 19, 2020. Research studies have demonstrated that geriatric population is vastly vulnerable to COVID-19 morbidity and mortality given their age and preexisting chronic comorbidities such as cardiovascular disease, hypertension, diabetes mellitus, chronic pulmonary and chronic kidney disease The data regarding susceptibility of elderly population to COVID-19 is accruing and suggests that factors like age, gender, chronic comorbidity, inflammaging, immunosenescence and renin angiotensin system may be the contributing risk factors towards COVID-19 and associated mortality in elderly population. Based on updated scientific literature, this narrative review précises the clinical presentations and underlying risk factors that might be associated with COVID-19 morbidity in geriatric population and provides informed insights, and discusses clinical presentation, psychosocial impact, mortality and potential corticosteroid treatment and prevention strategies of COVID-19 in older adults.
由严重急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的2019冠状病毒病已演变成一场致命的大流行病,甚至使世界上最好的医疗体系也不堪重负。截至2020年10月19日,全球已有40373228人受到影响,1119568人死亡。研究表明,老年人群由于年龄和诸如心血管疾病、高血压、糖尿病、慢性肺病和慢性肾病等既存慢性合并症,极易感染新冠病毒并出现发病和死亡情况。关于老年人群对新冠病毒易感性的数据不断增加,表明年龄、性别、慢性合并症、炎症衰老、免疫衰老和肾素血管紧张素系统等因素可能是导致老年人群感染新冠病毒及相关死亡的危险因素。基于最新的科学文献,本叙述性综述阐述了可能与老年人群新冠病毒发病相关的临床表现和潜在危险因素,并提供了有见地的观点,同时讨论了老年人新冠病毒病的临床表现、心理社会影响、死亡率以及潜在的皮质类固醇治疗和预防策略。