锡(ii)催化的 2H-色烯半缩醛与酮的脱水交叉偶联。
Tin(ii)-catalyzed dehydrative cross-coupling of 2H-chromene hemiacetals with ketones.
机构信息
School of Marine Science and Technology, Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai 264209, P. R. China.
出版信息
Org Biomol Chem. 2020 Dec 7;18(45):9308-9315. doi: 10.1039/d0ob01980a. Epub 2020 Nov 10.
PMID:33169768
Abstract
A dehydrative cross-coupling of 2H-chromene hemiacetals with ketones is described. Without the derivatization of 2H-chromene hemiacetals to 2H-chromene acetals, the direct C-OH/C-H coupling reaction has been accomplished with water as the only by-product. With the use of Sn(OTf) as the promoter, the reaction goes smoothly under mild conditions.
摘要
本文描述了 2H-色烯半缩醛与酮的脱水交叉偶联反应。在无需将 2H-色烯半缩醛衍生为 2H-色烯缩醛的情况下，通过直接 C-OH/C-H 偶联反应，以水为唯一副产物完成了反应。使用 Sn(OTf)作为促进剂，该反应在温和条件下顺利进行。
Zotero 插件