基于棕榈酰乙醇酰胺加橄榄树或假马齿苋提取物的羟基酪醇的膳食补充剂，用于治疗神经疾病。
Food supplements based on palmitoylethanolamide plus hydroxytyrosol from olive tree or Bacopa monnieri extracts for neurological diseases.
机构信息
MAGI EUREGIO, Bolzano, Italy.
Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy.
出版信息
Acta Biomed. 2020 Nov 9;91(13-S):e2020007. doi: 10.23750/abm.v91i13-S.10582.
Abstract
Neurological disorders like Parkinson disease and Alzheimer disease, spinal cord injury and stroke have some recurrent characteristics such as abnormal protein aggregation, oxidative stress induction, apoptosis, excitotoxicity, perturbation of intracellular Ca2+ homeostasis and inflammation. To date, there are few effective treatments available and the drugs currently used to manage the symptoms have important side effects. Therefore, research studies are focusing on natural phytochemicals present in diet as bioactive molecules potentially useful against neurodegenerative diseases. In this review, we will discuss the neuroprotective role of palmitoylethanolamide, hydroxytyrosol, and Bacopa monnieri extracts against neuroinflammation and neurodegeneration, thereby revealing their remarkable potential as novel therapeutic options for the treatment of neurodegenerative disorders.
摘要
神经紊乱疾病，如帕金森病和阿尔茨海默病、脊髓损伤和中风，具有一些反复出现的特征，如异常蛋白聚集、氧化应激诱导、细胞凋亡、兴奋性毒性、细胞内 Ca2+ 稳态紊乱和炎症。迄今为止，可用的有效治疗方法很少，目前用于治疗症状的药物有重要的副作用。因此，研究工作集中在饮食中的天然植物化学物质作为对抗神经退行性疾病的潜在生物活性分子。在这篇综述中，我们将讨论棕榈酰乙醇酰胺、羟基酪醇和假马齿苋提取物对神经炎症和神经退行性变的神经保护作用，从而揭示它们作为神经退行性疾病治疗新的治疗选择的显著潜力。
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2
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