Laboratory of Protein Dynamics, University of Debrecen, Hungary.
Department of Biomedical Sciences, University of Padova, Italy.
Biochem Soc Trans. 2020 Dec 18;48(6):2557-2564. doi: 10.1042/BST20200239.
Why proteins are fuzzy? Constant adaptation to the cellular environment requires a wide range of changes in protein structure and interactions. Conformational ensembles of disordered proteins in particular exhibit large shifts to activate or inhibit alternative pathways. Fuzziness is critical for liquid-liquid phase separation and conversion of biomolecular condensates into fibrils. Interpretation of these phenomena presents a challenge for the classical structure-function paradigm. Here I discuss a multi-valued formalism, based on fuzzy logic, which can be applied to describe complex cellular behavior of proteins.
为什么蛋白质是模糊的？为了不断适应细胞环境，蛋白质的结构和相互作用需要大范围的改变。无规卷曲蛋白质的构象集合尤其表现出较大的转变，以激活或抑制备用途径。模糊性对于液-液相分离以及生物分子凝聚物转化为纤维至关重要。这些现象的解释对经典的结构-功能范例提出了挑战。在这里，我讨论了一种基于模糊逻辑的多值形式主义，它可以应用于描述蛋白质的复杂细胞行为。
