ISF College of Pharmacy, Moga, Punjab, 142001, India.
Curr Mol Pharmacol. 2021;14(3):306-320. doi: 10.2174/1874467213999201109220714.
Vitiligo is an auto-immune disease with white-coloured disfiguring patches or spots on the skin surface. It is highly prevalent in several corners of the world. This disease spreads in different age groups.
The main aim of this review is to provide an overview of pathophysiology and lipid-based nano-carriers for the treatment of vitiligo.
The conventional delivery systems available have limited efficacy due to less retention of the drug in the epidermal layer where melanocytes reside. In order to overcome these issues, an advanced delivery system with lipid-based nano-carriers for the treatment of vitiligo was proven to be better as per the literature explored.
This review summarizes the pathophysiology along with novel lipid-based nano-carriers for the treatment of vitiligo.
Though various treatment regimens are present for the disease, nano-lipid carrier systems are significantly gaining importance nowadays, due to their high effectivity in topically acting on the target site. Nano-lipid carrier systems such as liposomes, ethosomes, transethosomes and transferosomes can be said to be at the top of the list in acting effectively against vitiligo or several other tropical diseases.
白癜风是一种自身免疫性疾病，其特征是皮肤表面出现白色的、毁容性的斑块或斑点。它在世界上的几个角落高度流行。这种疾病在不同的年龄组中传播。
本综述的主要目的是提供对白癜风的病理生理学和基于脂质的纳米载体治疗的概述。
由于药物在黑素细胞所在的表皮层中的保留较少，现有的常规递药系统的疗效有限。为了克服这些问题，根据已探索的文献，用于治疗白癜风的基于脂质的纳米载体的先进递药系统被证明效果更好。
本综述总结了白癜风的病理生理学以及新型基于脂质的纳米载体治疗方法。
尽管存在各种治疗方案，但由于纳米脂质载体系统在靶向部位的局部作用具有很高的效果，因此现在它们的重要性日益增加。脂质体、醇质体、转醇质体和传递体等纳米脂质载体系统可以说是在有效对抗白癜风或其他几种热带疾病方面处于领先地位。
