Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
School of Medicine, Zhejiang University City College, Hangzhou 310015, People's Republic of China.
Int J Nanomedicine. 2020 May 8;15:3267-3279. doi: 10.2147/IJN.S245326. eCollection 2020.
Vitiligo is a depigmentation disease that seriously affects the physical health, mental health and quality of life of a patient. Therapeutic aim at control immunoreaction by relieving oxidative stress. Unfortunately, the cuticle barrier function and lack of specific accumulation lead to unsatisfactory therapeutic outcomes and side effects. The introduction and innovation of nanotechnology offers inspiration and clues for the development of new strategies to treat vitiligo. However, not many studies have been done to interrogate how nanotechnology can be used for vitiligo treatment. In this review, we summarize and analyze recent studies involving nano-drug delivery systems for the treatment of vitiligo, with a special emphasis on liposomes, niosomes, nanohydrogel and nanoparticles. These studies made significant progress by either increasing drug loading efficiency or enhancing penetration. Based on these studies, there are three proposed principles for topical nano-drug delivery systems treatment of vitiligo including the promotion of transdermal penetration, enhancement of drug retention and facilitation of melanin regeneration. The presentation of these ideas may provide inspirations for the future development of topical drug delivery systems that will conquer vitiligo.
白癜风是一种色素脱失疾病，严重影响患者的身心健康和生活质量。治疗目标是通过缓解氧化应激来控制免疫反应。不幸的是，角质层屏障功能和缺乏特异性积累导致治疗效果和副作用不理想。纳米技术的引入和创新为开发治疗白癜风的新策略提供了灵感和线索。然而，目前还没有多少研究探讨纳米技术如何用于白癜风的治疗。在这篇综述中，我们总结和分析了最近涉及用于治疗白癜风的纳米药物传递系统的研究，特别强调了脂质体、非离子囊泡、纳米水凝胶和纳米粒子。这些研究通过提高药物载药量或增强穿透性取得了显著进展。基于这些研究，提出了三种用于白癜风局部纳米药物传递系统治疗的原则，包括促进经皮渗透、增强药物滞留和促进黑色素再生。这些想法的提出可能为未来征服白癜风的局部药物传递系统的发展提供灵感。
