Graduate School, Beijing University of Chinese Medicine, Beijing, China.
International Medical Services, China-Japan Friendship Hospital, Beijing, China.
Pediatr Res. 2021 Jul;90(1):223-231. doi: 10.1038/s41390-020-01233-4. Epub 2020 Nov 10.
We aimed to identify potential risk factors for recurrent respiratory tract infection among Chinese preschool-aged children, and further to construct a nomogram prediction model.
This is a cross-sectional survey conducted in Beijing. Utilizing a stratified cluster random sampling strategy, a total of 7222 children from 20 kindergartens were enrolled. Data are analyzed by STATA software and R language.
Five independent factors were identified to be significantly associated with recurrent respiratory tract infection risk overall and by pathogenic sites. The significant odds of recurrent respiratory tract infection was 8.31 (95% confidence interval [CI]: 5.69-12.12, P < 0.001), 2.31 (2.06-2.58, P < 0.001), 1.72 (1.48-1.99, P < 0.001), 1.24 (1.08-1.43, P = 0.002), and 1.19 (1.09-1.31, P < 0.001) for asthma, allergy, initial use of antibiotics <6 months, breastfeeding duration <6 months, and maternal body mass index, respectively. Besides the leading role played by asthma, allergy, initial use of antibiotics, and breastfeeding might exert a graded, dose-dependent effect on recurrent respiratory tract infection susceptibility.
We have identified five potential risk factors for the risk of recurrent respiratory tract infection from 7222 preschool-aged Chinese children. Notably, asthma plays a leading role, and allergy, initial use of antibiotics, and breastfeeding might exert a graded, dose-dependent effect on recurrent respiratory tract infection susceptibility.
This is the first report of examining the joint contribution of multiple potential risk factors to recurrent respiratory tract infection among Chinese preschool-aged children. We have identified five potential risk factors for the risk of recurrent respiratory tract infection via analyzing survey data from 7222 preschool-aged Chinese children. Asthma plays a leading role, and allergy, initial use of antibiotics, and breastfeeding might exert a graded, dose-dependent effect on recurrent respiratory tract infection susceptibility.
本研究旨在识别中国学龄前儿童反复呼吸道感染的潜在危险因素，并进一步构建列线图预测模型。
这是一项在北京进行的横断面调查。采用分层整群随机抽样策略，共纳入 20 所幼儿园的 7222 名儿童。数据分析采用 STATA 软件和 R 语言。
总体上和按病原部位分层，共确定了 5 个与反复呼吸道感染风险显著相关的独立因素。反复呼吸道感染的显著优势比为 8.31（95%置信区间：5.69-12.12，P<0.001）、2.31（2.06-2.58，P<0.001）、1.72（1.48-1.99，P<0.001）、1.24（1.08-1.43，P=0.002）和 1.19（1.09-1.31，P<0.001），分别对应哮喘、过敏、抗生素初始使用<6 个月、母乳喂养<6 个月和母亲体质指数。除了哮喘起主导作用外，过敏、抗生素初始使用和母乳喂养可能对反复呼吸道感染的易感性产生分级、剂量依赖性的影响。
本研究从 7222 名学龄前中国儿童中确定了 5 个反复呼吸道感染的潜在危险因素。值得注意的是，哮喘起主导作用，过敏、抗生素初始使用和母乳喂养可能对反复呼吸道感染的易感性产生分级、剂量依赖性的影响。
这是首次研究中国学龄前儿童多个潜在危险因素对反复呼吸道感染的联合贡献。我们通过分析 7222 名学龄前中国儿童的调查数据，确定了反复呼吸道感染的 5 个潜在危险因素。哮喘起主导作用，过敏、抗生素初始使用和母乳喂养可能对反复呼吸道感染的易感性产生分级、剂量依赖性的影响。
