Gorczyca Daiva, Szeremeta Karolina, Paściak Mariola, Szponar Bogumiła, Zhao Longgang, Wirth Michael D, Hebert James R, Związek Natalia, Prescha Anna
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Berlin zu Berlin, Center for Chronically Sick Children Berlin, Augustenburger Platz 1, 13353 Berlin, Germany.
The Faculty of Medicine, Wroclaw Medical University, Pasteura 1, 50-367 Wroclaw, Poland.
Nutrients. 2024 Dec 31;17(1):153. doi: 10.3390/nu17010153.
To assess the associations between serum and dietary polyunsaturated fatty acids (PUFAs), as well as the inflammatory potential of diet measured by the Children's Dietary Inflammatory Index (C-DII), and recurrent respiratory infections (RRIs) in children. We enrolled 44 children aged 3-16 years with RRIs and 44 healthy controls. Dietary intake was assessed using a 7-day food record from which PUFA intake and C-DII were calculated. Serum PUFA levels were determined using gas-liquid chromatography-mass spectrometry. The dietary assessment showed a significantly lower fiber intake in children with RRIs. The RRI group had a higher inflammatory potential in the diet than healthy controls. Children with RRIs have higher serum levels of linoleic, arachidonic, and eicosapentaenoic acids than healthy subjects. A pro-inflammatory diet was positively associated with serum -6 PUFA levels in both the groups. A high inflammatory potential of diet, body mass index over 75 percentile, and short breastfeeding duration were identified as risk factors for RRIs. The inflammatory potential of diet is strongly associated with RRIs in children and related to their PUFA status. Promoting breastfeeding and healthy dietary habits during childhood are crucial for implementing effective preventive management strategies.
评估血清和膳食多不饱和脂肪酸（PUFA）之间的关联，以及通过儿童膳食炎症指数（C-DII）衡量的饮食炎症潜能与儿童反复呼吸道感染（RRI）之间的关联。我们招募了44名3至16岁患有RRI的儿童和44名健康对照。使用7天食物记录评估膳食摄入量，并据此计算PUFA摄入量和C-DII。采用气液色谱-质谱法测定血清PUFA水平。膳食评估显示，患有RRI的儿童膳食纤维摄入量显著较低。RRI组饮食中的炎症潜能高于健康对照组。患有RRI的儿童血清亚油酸、花生四烯酸和二十碳五烯酸水平高于健康受试者。两组中，促炎饮食均与血清ω-6 PUFA水平呈正相关。饮食炎症潜能高、体重指数超过第75百分位数以及母乳喂养时间短被确定为RRI的危险因素。饮食炎症潜能与儿童RRI密切相关，并与其PUFA状态有关。在儿童期促进母乳喂养和健康饮食习惯对于实施有效的预防管理策略至关重要。
